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12474_3882980_pozoclaret_tem_2018.pdf (1.16 MB)

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Article

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Accepted version

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2018-01-01

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cc by-nc-nd (c) Elsevier, 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/146158

Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection

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https://doi.org/10.1016/j.tem.2018.05.001

Abstract

Maintenance of glucose homeostasis is mandatory for organismal survival. It is accomplished by complex and coordinated interplay between glucose detection mechanisms and multiple effector systems. The brain, in particular homeostatic regions such as the hypothalamus, plays a crucial role in orchestrating such a highly integral response. We review here current understanding of how the hypothalamus senses glucose availability and participates in systemic glucose homeostasis. We provide an update of the relevant signaling pathways and neuronal subsets involved, as well as of the mechanisms modulating metabolic processes in peripheral tissues such as liver, skeletal muscle, fat, and especially the pancreas. We also discuss the relevance of these networks in human biology and prevalent metabolic conditions such as diabetes and obesity.

Subject

Homeòstasi, Hipotàlem

Subject (English)

Homeostasis, Hypothalamus

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

CLARET I CARLES, Marc and POZO, Macarena. Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection. Trends in Endocrinology & Metabolism. 2018. Vol. 29, num. 8, pags. 581-594. ISSN 1043-2760. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/146158

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