Miniatura

Fitxers

jcm-10-00989.pdf (1.02 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2021-03-02

Llicència de publicació

cc by (c) Marazuela et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/175995

Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/jcm10050989

Resum

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 +/- 18.6 months) and long-term (38.5 +/- 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as >= 2 lobar ICHs and >= 5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.

Matèries

Hemorràgia, Malalties del sistema nerviós central, Ressonància magnètica

Matèries (anglès)

Hemorrhage, Central nervous system diseases, Magnetic resonance

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MARAZUELA, Paula, BONATERRA PASTRA, Anna, FAURA, Júlia, PENALBA, Anna, PIZARRO, Jesús, PANCORBO, Olalla, RODRÍGUEZ LUNA, David, VERT, Carla, ROVIRA, Alex, PUJADAS, Francesc, FREIJO, M. mar, TUR, Silvia, MARTÍNEZ ZABALETA, Maite, CARDONA PORTELA, Pere, VERA, Rocío, LEBRATO HERNÁNDEZ, Lucia, ARENILLAS, Juan f., PÉREZ SÁNCHEZ, Soledad, MONTANER, Joan, DELGADO, Pilar, HERNÁNDEZ GUILLAMON, Mar. Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage. _Journal of Clinical Medicine_. 2021. Vol. 10, núm. 5. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/175995]

Exportar metadades

JSON - METS

Compartir registre