Miniatura

Fitxers

BrennerDR.pdf (220.5 KB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2019-02-01

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171670

Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.canep.2018.10.006

Resum

Background: There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders. Methods: Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type. Results: We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for >= 20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90). Conclusions: Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

Matèries

Càncer de pulmó, Alcoholisme

Matèries (anglès)

Lung cancer, Alcoholism

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BRENNER, Darren r., FEHRINGER, Gord, ZHANG, Zuo-feng, LEE, Yuan-chin, MEYERS, Travis, MATSUO, Keitaro, ITO, Hidemi, VINEIS, Paolo, STUCKER, Isabelle, BOFFETTA, Paolo, BRENNAN, Paul, CHRISTIANI, David c., DIAO, Nancy, HONG, Yun-chul, LANDI, Maria t., MORGENSTERN, Hal, SCHWARTZ, Ann g., RENNERT, Gad, SALIBA, Walid, MCLAUGHLIN, John r., HARRIS, Curtis c., ORLOW, Irene, BARROS DIOS, Juan m., RUANO-RAVINA, Alberto, SIEMIATYCKI, Jack, KOUSHIK, Anita, COTÉ, Michele l., LAZARUS, Philip, FERNÁNDEZ TARDÓN, Guillermo, TARDÓN, Adonina, MARCHAND, Loïc le, BRENNER, Hermann, SAUM, Kai-uwe, DUELL, Eric j., ANDREW, Angeline s., CONSONNI, Dario, OLSSON, Ann, HUNG, Rayjean j., STRAIF, Kurt. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. _Cancer Epidemiology_. 2019-02-01. Vol. 58, núm. 25-32. [consulta: 26 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/171670]

Exportar metadades

JSON - METS

Compartir registre