Miniatura

Fitxers

624034.pdf (2.96 MB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2014

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171748

Urolithins Are the Main Urinary Microbial-Derived Phenolic Metabolites Discriminating a Moderate Consumption of Nuts in FreeLiving Subjects with Diagnosed Metabolic Syndrome

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1021/jf301509w

Resum

Walnuts (Juglans regia L.), hazelnuts (Corylus avellana L.), and almonds (Prunus dulcis Mill.) are rich sources of ellagitannins and proanthocyanidins. Gut microbiota plays a crucial role in modulating the bioavailability of these high molecular weight polyphenols. However, to date there are no studies evaluating the capacity to produce nut phenolic metabolites in subjects with metabolic syndrome (MetS), a pathology associated with an altered gut bacterial diversity. This study applied a LC-MS targeted approach to analyze the urinary excretion of nut phenolic metabolites in MetS subjects following 12 weeks of nut consumption, compared to sex- and age-matched individuals given a nut-free control diet. Metabolites were targeted in both hydrolyzed and nonhydrolyzed urine by LC-PDA-QqQ-MS/MS analysis, and identification of metabolites lacking available standards was confirmed by LC-ESI-ITD-FT-MS. Ellagitannin-derived urolithins A and B significantly increased after the nutenriched-diet, urolithins C and D were also detected, and a complex combination of urolithin-conjugated forms was observed in nonhydrolyzed urine, confirming an extensive phase II metabolism after absorption. In contrast, no significant increases in proanthocyanidin microbial metabolites were observed in urine following nut consumption. Because the intestinal microbiota of the subjects in this study could catabolize ellagitannins into a wide range of urolithins, further research is strongly warranted on the in vivo potential of these microbial metabolites in reducing cardiometabolic risk.

Matèries

Polifenols, Fenols, Fruita seca, Síndrome metabòlica, Microbiota

Matèries (anglès)

Polyphenols, Phenols, Dried fruit, Metabolic syndrome, Microbiota

Citació

Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

Citació

TULIPANI, Sara, URPÍ SARDÀ, Mireia, GARCIA VILLALBA, Rocio, RABASSA BONET, Montserrat, LOPEZ-URIARTE, Patricia, BULLÓ, Mònica, JÁUREGUI PALLARÉS, Olga, TOMAS-BARBERAN, F. a. (francisco a.), SALAS SALVADÓ, Jordi, ESPÍN, Juan carlos, ANDRÉS LACUEVA, Ma. cristina. Urolithins Are the Main Urinary Microbial-Derived Phenolic Metabolites Discriminating a Moderate Consumption of Nuts in FreeLiving Subjects with Diagnosed Metabolic Syndrome. _Journal of Agricultural and Food Chemistry _. 2012. Vol. 60, núm. 36, pàgs. 8930-8940. [consulta: 23 de gener de 2026]. ISSN: 0021-8561. [Disponible a: https://hdl.handle.net/2445/171748]

Exportar metadades

JSON - METS

Compartir registre