Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/194641
Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Genetic variants in YWHAZ contribute to psychiatric disorders such as autism spectrum disorder and schizophrenia, and have been related to an impaired neurodevelopment in humans and mice. Here, we have used zebrafish to investigate the mechanisms by which YWHAZ contributes to neurodevelopmental disorders. We observed that ywhaz expression was pan-neuronal during developmental stages and restricted to Purkinje cells in the adult cerebellum, cells that are described to be reduced in number and size in autistic patients. We then performed whole-brain imaging in wild-type and ywhaz CRISPR/Cas9 knockout (KO) larvae and found altered neuronal activity and connectivity in the hindbrain. Adult ywhaz KO fish display decreased levels of monoamines in the hindbrain and freeze when exposed to novel stimuli, a phenotype that can be reversed with drugs that target monoamine neurotransmission. These findings suggest an important role for ywhaz in establishing neuronal connectivity during development and modulating both neurotransmission and behaviour in adults.
Matèries
Matèries (anglès)
Citació
Citació
ANTÓN GALINDO, Ester, DALLA VECCHIA, Elisa, ORLANDI, Javier g., CASTRO, Gustavo, GUALDA, Emilio j., YOUNG, Andrew m.j., GUASCH-PIQUERAS, Marc, ARENAS SOLÀ, Concepción, HERRERA ÚBEDA, Carlos, GARCIA FERNÁNDEZ, Jordi, AGUADO TOMÀS, Fernando, LOZA-ALVAREZ, Pablo, CORMAND RIFÀ, Bru, NORTON, William h.j., FERNÀNDEZ CASTILLO, Noèlia. Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish. _Molecular Psychiatry_. 2022. Vol. 27, núm. 9, pàgs. 3739-3748. [consulta: 21 de gener de 2026]. ISSN: 1359-4184. [Disponible a: https://hdl.handle.net/2445/194641]