The impact of p16(ink4a) positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study

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dc.contributor.authorGensthaler, Lisa
dc.contributor.authorJoura, Elmar A.
dc.contributor.authorAlemany i Vilches, Laia
dc.contributor.authorHorvat, Reinhard
dc.contributor.authorSanjosé Llongueras, Silvia de
dc.contributor.authorPils, Sophie
dc.date.accessioned2021-01-20T17:30:13Z
dc.date.available2021-01-20T17:30:13Z
dc.date.issued2020-03-01
dc.date.updated2020-12-21T13:16:45Z
dc.description.abstractPurpose To evaluate HPV and p16(ink4a) status as prognostic factors in patients with invasive vulvar cancer. Methods Retrospective analysis of disease-free (DFS) and disease-specific survival (DSS) of patients with invasive vulvar cancer at a single tertiary care center. Histology, HPV and p16(ink4a) status were evaluated in the context of a global multicenter trial. Logistic regression models were performed to identify the impact of p16(ink4a) positivity. Results 135 patients were included in the analysis. 32 (23.7%) showed a p16(ink4a) expression of over 25%. Disease-free and disease-specific survival was longer in p16(ink4a) positive patients (23 vs. 10 months, p = 0.004, respectively, 29 vs. 21 months, p = 0.016). In multivariate analysis, p16(ink4a) positivity was an independent parameter for DFS (p = 0.025, HR: 2.120 (1.100-4.085)), but not for DSS (p = 0.926, HR: 1.029 (0.558-1.901), in contrast to age and tumor stage. Conclusions Age and tumor stage negatively affect survival. However, disease-free survival is significantly longer in patients with p16(ink4a) positive invasive vulvar cancer.
dc.format.extent6 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid31970493
dc.identifier.urihttps://hdl.handle.net/2445/173258
dc.language.isoeng
dc.publisherSpringer Heidelberg
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1007/s00404-020-05431-7
dc.relation.ispartofArchives of Gynecology and Obstetrics, 2020, vol. 301, num. 3, p. 753-759
dc.relation.urihttps://doi.org/10.1007/s00404-020-05431-7
dc.rightscc by (c) Gensthaler et al., 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationPapil·lomavirus
dc.subject.classificationCàncer ginecològic
dc.subject.classificationPronòstic mèdic
dc.subject.otherPapillomaviruses
dc.subject.otherGynecologic cancer
dc.subject.otherPrognosis
dc.titleThe impact of p16(ink4a) positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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