Document type
ArticleVersion
Accepted versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/218811
Bridging the critically ill patient with acute to chronic liver failure to liver transplantation
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
Liver transplantation (LT) has emerged as an effective therapy for severe forms of acute-onchronic liver failure (ACLF), an entity characterized by the development of multiorgan failure and high short-term mortality. The aim of critical care management of ACLF patients is to rapidly treat precipitating events and aggressively support failing organs to ensure that patients may successfully undergo LT or, less frequently, recover. Malnutrition and sarcopenia are frequently present, adversely impacting the prognosis of these patients. Management of critical care patients with ACLF is complex and requires the participation of different specialties. Once the patient is stabilized, a rapid evaluation for salvage LT should be performed because the time window for LT is often narrow. The development of sepsis and prolonged organ support may preclude LT or diminish its chances of success. The current review describes strategies to bridge severe ACLF patients to LT, highlights the minimal evaluation required for listing and the currently suggested contraindications to proceed with LT, and addresses different aspects of management during the perioperative and early posttransplant period.
Related resource
Subject
Subject (English)
Citation
Citation
FERNÁNDEZ GÓMEZ, Javier, et al. Bridging the critically ill patient with acute to chronic liver failure to liver transplantation. American Journal Of Transplantation. 2024. Vol. 24, num. 8, pags. 1348-1361. ISSN 1600-6143. [consulted: 12 of October of 2026]. Available at: https://hdl.handle.net/2445/218811