Carregant...
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/214528
Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients remain unresponsive or develop resistance. Here, we show that, during cSCC progression in male mice, cancer cells acquire epithelial/mesenchymal plasticity and change their immune checkpoint (IC) ligand profile according to their features, dictating the IC pathways involved in immune evasion. Epithelial cancer cells, through the PD-1/PD-L1 pathway, and mesenchymal cancer cells, through the CTLA-4/CD80 and TIGIT/CD155 pathways, differentially block antitumor immune responses and determine the response to ICB therapies. Accordingly, the anti-PD-L1/TIGIT combination is the most effective strategy for blocking the growth of cSCCs that contain both epithelial and mesenchymal cancer cells. The expression of E-cadherin/Vimentin/CD80/CD155 proteins in cSCC, HNSCC and melanoma patient samples predicts response to anti-PD-1/PD-L1 therapy. Collectively, our findings indicate that the selection of ICB therapies should take into account the epithelial/mesenchymal features of cancer cells. Immune surveillance is critical to prevent the development and progression of cutaneous squamous cell carcinoma (cSCC). Here, the authors show that epithelial-mesenchymal plasticity in cancer cells is associated with changes in their immune checkpoint ligand profile during mouse cSCC progression, which dictates differential responses to immune checkpoint blockade.
Matèries
Matèries (anglès)
Citació
Citació
LORENZO SANZ, Laura, LOPEZ CERDA, Marta, SILVA DIZ, Victoria da, ARTÉS, Marta h., LLOP, Sandra, PENÍN, Rosa maria, BERMEJO, Josep oriol, GONZALEZ SUAREZ, Eva, ESTELLER, Manel, VIÑALS CANALS, Francesc, ESPINOSA, Enrique, OLIVA, Marc, PIULATS, Josep m., MARTIN LIBERAL, Juan, MUÑOZ MORUNO, Purificación. Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma. _Nature Communications_. 2024. Vol. 15, núm. 1. [consulta: 23 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/214528]