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Genetic Susceptibility to Chronic Lymphocytic Leukemia

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dc.contributor.authorSlager, Susan L.
dc.contributor.authorCaporaso, Neil E.
dc.contributor.authorSanjosé Llongueras, Silvia de
dc.contributor.authorGoldin, Lynn R.
dc.date.accessioned2018-11-23T14:12:43Z
dc.date.available2018-11-23T14:12:43Z
dc.date.issued2013-10
dc.date.updated2018-07-24T12:45:40Z
dc.description.abstractChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL. (C) 2013 Elsevier Inc. All rights reserved.
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid24246697
dc.identifier.urihttps://hdl.handle.net/2445/126406
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1053/j.seminhematol.2013.09.007
dc.relation.ispartofSeminars in Hematology, 2013, vol. 50, num. 4, p. 296-302
dc.relation.urihttps://doi.org/10.1053/j.seminhematol.2013.09.007
dc.rights(c) Elsevier, 2013
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationLeucèmia limfocítica crònica
dc.subject.classificationEtiologia
dc.subject.otherChronic lymphocytic leukemia
dc.subject.otherEtiology
dc.titleGenetic Susceptibility to Chronic Lymphocytic Leukemia
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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