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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223267
Editorial: Purinergic Signaling 2020: the State-of-The-Art commented by the members of the Italian Purine Club
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The “purinergic signaling” term was coined in 1972 by Geoffrey Burnstock Burnstock et al. after demonstrating that adenosine 5’-triphosphate (ATP) is a transmitter in nonadrenergic, noncholinergic inhibitory nerves innervating the guinea-pig taenia coli (Burnstock et al., 1966). This signaling system, which is ubiquitously expressed in every organ and system of the body, comprises various ecto-, soluble and intracellularly localized enzymes, nucleoside transporters, and G protein-coupled and ligand-gated cation channel receptors. Through the purinergic signaling
system cells can maintain basal adenine and guanine-based purines at certain steady-state levels, thereby contributing to preserve the purines-dependent cellular homeostasis.
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CIRUELA ALFÉREZ, Francisco, FUXE, Kjell, ILLES, Peter, ULRICH, Henning, CACIAGLI, Francesco. Editorial: Purinergic Signaling 2020: the State-of-The-Art commented by the members of the Italian Purine Club. _Frontiers in Pharmacology_. 2021. Vol. 12. [consulta: 10 de gener de 2026]. ISSN: 1663-9812. [Disponible a: https://hdl.handle.net/2445/223267]