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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/223267
Editorial: Purinergic Signaling 2020: the State-of-The-Art commented by the members of the Italian Purine Club
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The “purinergic signaling” term was coined in 1972 by Geoffrey Burnstock Burnstock et al. after demonstrating that adenosine 5’-triphosphate (ATP) is a transmitter in nonadrenergic, noncholinergic inhibitory nerves innervating the guinea-pig taenia coli (Burnstock et al., 1966). This signaling system, which is ubiquitously expressed in every organ and system of the body, comprises various ecto-, soluble and intracellularly localized enzymes, nucleoside transporters, and G protein-coupled and ligand-gated cation channel receptors. Through the purinergic signaling
system cells can maintain basal adenine and guanine-based purines at certain steady-state levels, thereby contributing to preserve the purines-dependent cellular homeostasis.
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CIRUELA ALFÉREZ, Francisco, et al. Editorial: Purinergic Signaling 2020: the State-of-The-Art commented by the members of the Italian Purine Club. Frontiers in Pharmacology. 2021. Vol. 12. ISSN 1663-9812. [consulted: 14 of October of 2026]. Available at: https://hdl.handle.net/2445/223267