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s13046-022-02264-x.pdf (2.51 MB)

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2022-02-14

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cc by (c) Archilla Ortega, Adrià et al, 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183764

Blockade of novel immune checkpoints and new therapeutic combinations to boost antitumor immunity

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https://doi.org/10.1186/s13046-022-02264-x

Resum

Immunotherapy has emerged as a promising strategy for boosting antitumoral immunity. Blockade of immune checkpoints (ICs), which regulate the activity of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells has proven clinical benefits. Antibodies targeting CTLA-4, PD-1, and PD-L1 are IC-blockade drugs approved for the treatment of various solid and hematological malignancies. However, a large subset of patients does not respond to current anti-IC immunotherapy. An integrative understanding of tumor-immune infiltrate, and IC expression and function in immune cell populations is fundamental to the design of effective therapies. The simultaneous blockade of newly identified ICs, as well as of previously described ICs, could improve antitumor response. We review the potential for novel combinatory blockade strategies as antitumoral therapy, and their effects on immune cells expressing the targeted ICs. Preclinical evidence and clinical trials involving the blockade of the various ICs are reported. We finally discuss the rationale of IC co-blockade strategy with respect to its downstream signaling in order to improve effective antitumoral immunity and prevent an increased risk of immune-related adverse events (irAEs).

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Immunoteràpia, Cèl·lules T

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Immunotherapy, T cells

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

ARCHILLA ORTEGA, Adrià, DOMURO, Carla, MARTIN LIBERAL, Juan, MUÑOZ MORUNO, Purificación. Blockade of novel immune checkpoints and new therapeutic combinations to boost antitumor immunity. _Journal of Experimental & Clinical Cancer Research_. 2022. Vol.  vol 41, núm. num 1. [consulta: 26 de febrer de 2026]. ISSN: 1756-9966. [Disponible a: https://hdl.handle.net/2445/183764]

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