Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells

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dc.contributor.authorGandioso, Albert
dc.contributor.authorMassaguer i Vall-llovera, Anna
dc.contributor.authorVillegas, Núria
dc.contributor.authorSalvans, Cándida
dc.contributor.authorSánchez, Dani
dc.contributor.authorBrun Heath, Isabelle
dc.contributor.authorMarchán Sancho, Vicente
dc.contributor.authorOrozco López, Modesto
dc.contributor.authorTerrazas Martínez, Montserrat
dc.date.accessioned2017-05-09T13:25:52Z
dc.date.available2018-12-31T06:10:19Z
dc.date.issued2017-02-13
dc.date.updated2017-05-09T13:25:52Z
dc.description.abstractDespite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different size and complexity. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec667552
dc.identifier.issn1359-7345
dc.identifier.urihttps://hdl.handle.net/2445/110712
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1039/C6CC10287E
dc.relation.ispartofChemical Communications, 2017, vol. 53, num. 19, p. 2870-2873
dc.relation.urihttps://doi.org/10.1039/C6CC10287E
dc.rights(c) Gandioso et al., 2017
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationRNA
dc.subject.classificationPèptids
dc.subject.classificationCàncer de mama
dc.subject.classificationCèl·lules canceroses
dc.subject.otherRNA
dc.subject.otherPeptides
dc.subject.otherBreast cancer
dc.subject.otherCancer cells
dc.titleEfficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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