Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/199433
The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Hair cell (HC) loss by epithelial extrusion has been described to occur in the rodent vestibular system during chronic 3,3'-iminodipropionitrile (IDPN) ototoxicity. This is preceded by dismantlement of the calyceal junction in the contact between type I HC (HCI) and calyx afferent terminals. Here, we evaluated whether these phenomena have wider significance. First, we studied rats receiving seven different doses of streptomycin, ranging from 100 to 800 mg/kg/day, for 3 to 8 weeks. Streptomycin caused loss of vestibular function associated with partial loss of HCI and decreased expression of contactin-associated protein (CASPR1), denoting calyceal junction dismantlement, in the calyces encasing the surviving HCI. Additional molecular and ultrastructural data supported the conclusion that HC-calyx detachment precede HCI loss by extrusion. Animals allowed to survive after the treatment showed functional recuperation and rebuilding of the calyceal junction. Second, we evaluated human sensory epithelia obtained during therapeutic labyrinthectomies and trans-labyrinthine tumour excisions. Some samples showed abnormal CASPR1 label strongly suggestive of calyceal junction dismantlement. Therefore, reversible dismantlement of the vestibular calyceal junction may be a common response triggered by chronic stress, including ototoxic stress, before HCI loss. This may partly explain clinical observations of reversion in function loss after aminoglycoside exposure.
Matèries (anglès)
Citació
Citació
MAROTO, Alberto f., BORRAJO, Mireia, PRADES, Sílvia, CALLEJO CASTILLO, Àngela, AMILIBIA, Emilio, PÉREZ-GRAU, Marta, ROCA RIBAS, Francesc, CASTELLANOS, Elisabeth, BARRALLO GIMENO, Alejandro, LLORENS I BAUCELLS, Jordi. The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans. _Archives of Toxicology_. 2023. Vol. 97, núm. 1943-1961. [consulta: 23 de gener de 2026]. ISSN: 0340-5761. [Disponible a: https://hdl.handle.net/2445/199433]