Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171669
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206(+)CD163(+) tumor-associated macrophages and vessels. Proteomic analysis shows that ROCK Myosin II activity in amoeboid cancer cells controls an immunomodulatory secretome, enabling the recruitment of monocytes and their differentiation into tumor-promoting macrophages. Both amoeboid cancer cells and their associated macrophages support an abnormal vasculature, which ultimately facilitates tumor progression. Mechanistically, amoeboid cancer cells perpetuate their behavior via ROCK-Myosin II-driven IL-alpha secretion and NF-kappa B activation. Using an array of tumor models, we show that high Myosin II activity in tumor cells reprograms the innate immune microenvironment to support tumor growth. We describe an unexpected role for Myosin II dynamics in cancer cells controlling myeloid function via secreted factors.
Matèries (anglès)
Citació
Citació
GEORGOULI, Mirella, HERRAIZ, Cecilia, CROSAS MOLIST, Eva, FANSHAWE, Bruce, MAIQUES, Oscar, PERDRIX ROSELL, Anna, PANDYA, Pahini, RODRÍGUEZ HERNÁNDEZ, Irene, ILIEVA, Kristina m., CANTELLI, Gaia, KARAGIANNIS, Panagiotis, MELE, Silvia, LAM, Hoyin, JOSEPHS, Debra h., MATIAS-GUIU, Xavier, MARTI, Rosa m., NESTLE, Frank o., ORGAZ, Jose l., MALANCHI, Ilaria, FRUHWIRTH, Gilbert o., KARAGIANNIS, Sophia n., SANZ MORENO, Victoria. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. _Cell_. 2019-02-07. Vol. 176, núm. Issue 4, pàgs. 757-774. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/171669]