Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/221148
Comparative analysis of palladium, nickel and copper phosphane/carbene catalysts in Suzuki–Miyaura couplings: Mechanistic insights and reactivity trends
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Suzuki–Miyaura coupling is a useful synthetic method of the formation of new car- bon–carbon bonds between an organic halide and a boronic acid (or boronate ester), generally catalyzed by palladium compounds in the presence of an external base. In the search of more sustainable and green chemistry processes, precious metals such as palladium are currently being replaced by base metal analogues, which produce more affordable and accessible catalytic platforms. In this work, the catalytic cycle of the Suzuki–Miyaura coupling reaction between phenyl bromide and phenylboronate has been studied by computational means for different combinations of metal/ligand systems. Three transition metals: palladium, nickel, and copper, and four monodentate ligands, including two phosphanes (PMe3 and P(CF3)3) and two N-heterocyclic carbenes (1,3-bis(methyl)imidazol-2-ylidene and 1,3-bis(trifluoromethyl)limidazol-2-ylidene), have been used to construct and explore the reaction for monoligated catalytic species. Overall, the palladium systems display the lowest activation barriers for the Suzuki–Miyaura reaction, with nickel producing the second-best catalysts. On the other hand, copper seems to produce slightly worse systems, with reaction barriers over 25 kcal mol−1 for all the ligands.
Matèries
Citació
Citació
GÓMEZ-MUDARRA, Francisco a., AULLÓN LÓPEZ, Gabriel, JOVER MODREGO, Jesús. Comparative analysis of palladium, nickel and copper phosphane/carbene catalysts in Suzuki–Miyaura couplings: Mechanistic insights and reactivity trends. _Advances in Inorganic Chemistry_. 2024. Vol. 84, núm. 219-258. [consulta: 30 de desembre de 2025]. ISSN: 0898-8838. [Disponible a: https://hdl.handle.net/2445/221148]