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Article

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Accepted version

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2010-04-30

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/54980

First enantioselective synthesis of isagarin, a natural product isolated from Pentas longiflora Oliv.

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http://dx.doi.org/10.1016/j.tet.2010.04.105

Abstract

For the first time, an enantioselective synthesis of both 1R,4S-isagarin 1a and 1S,4R-isagarin 1b was achieved starting from 1,4-dimethoxy-2-vinylnaphtalene 2. The key steps involve a Sharpless asymmetric dihydroxylation and reaction with an acetonylating pyridinium ylid.

Subject

Síntesi asimètrica, Productes naturals

Subject (English)

Asymmetric synthesis, Natural products

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

JACOBS, Jan, et al. First enantioselective synthesis of isagarin, a natural product isolated from Pentas longiflora Oliv. Tetrahedron. 2010. Vol. 66, num. 27-28, pags. 5158-5160. ISSN 0040-4020. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/54980

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