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2020-05-19

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cc by (c) Labadie et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174373

Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location

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https://doi.org/10.1093/jncics/pkaa042

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Background: Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogeneous disease, we evaluated whether the association of HT and CRC differs across etiologically relevant, molecularly defined tumor subtypes and tumor location. Methods: We pooled data on tumor subtypes (microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, pathway: adenoma-carcinoma, alternate, serrated), tumor location (proximal colon, distal colon, rectum), and HT use among 8220 postmenopausal women (3898 CRC cases and 4322 controls) from 8 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association of ever vs never HT use with each tumor subtype compared with controls. Models were adjusted for study, age, body mass index, smoking status, and CRC family history. All statistical tests were 2-sided. Results: Among postmenopausal women, ever HT use was associated with a 38% reduction in overall CRC risk (OR =0.62, 95% CI = 0.56 to 0.69). This association was similar according to microsatellite instability, CpG island methylator phenotype and BRAF or KRAS status. However, the association was attenuated for tumors arising through the serrated pathway (OR = 0.81, 95% CI = 0.66 to 1.01) compared with the adenoma-carcinoma pathway (OR = 0.63, 95% CI = 0.55 to 0.73; P het =.04) and alternate pathway (OR = 0.61, 95% CI = 0.51 to 0.72). Additionally, proximal colon tumors had a weaker association (OR = 0.71, 95% CI = 0.62 to 0.80) compared with rectal (OR = 0.54, 95% CI = 0.46 to 0.63) and distal colon (OR = 0.57, 95% CI = 0.49 to 0.66; P het =.01) tumors. Conclusions: We observed a strong inverse association between HT use and overall CRC risk, which may predominantly reflect a benefit of HT use for tumors arising through the adenoma-carcinoma and alternate pathways as well as distal colon and rectal tumors.

Matèries

Hormonoteràpia, Càncer colorectal

Matèries (anglès)

Hormone therapy, Colorectal cancer

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Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

LABADIE, Julia d., HARRISON, Tabitha a., BANBURY, Barbara l., AMTAY, Efrat l., BERNDT, Sonja i., BRENNER, Hermann, BUCHANAN, Daniel d., CAMPBELL, Peter t., CAO, Yin, CHAN, Andrew t., CHANG-CLAUDE, Jenny, ENGLISH, Dallas r., FIGUEIREDO, Jane c., GALLINGER, Steven, GILES, Graham g., GUNTER, Marc j., HOFFMEISTER, Michael, HSU, Li, JENKINS, Mark a., LIN, Yi, MILNE, Roger l., MORENO AGUADO, Víctor, MURPHY, Neil, OGINO, Shuji, PHIPPS, Amanda i., SAKODA, Lori c., SLATTERY, Martha l., SOUTHEY, Melissa c., SUN, Wei, THIBODEAU, Stephen n., VAN GUELPEN, Bethany, ZAIDI, Syed h., PETERS, Ulrike, NEWCOMB, Polly a.. Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location. _JNCI Cancer Spectrum_. 2020. Vol. 4, núm. 5. [consulta: 28 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/174373]

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