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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/187056
Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients
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Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when <20% of recruitment target was achieved. A Bayesian-adaptive individual patient data metaanalysis was implemented. Outpatients aged >= 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution.
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ROKX, Casper, LAMMERS, Jolanda, BUITENHUIS, Lonneke, POSTMA, Douwe, KOSTER, David, LUKENS, Michaèl, SCHOLTENS, Thea, BOOMGAARD, Maartje van den, KAMPSCHREUR, Linda, UBALS CAZORLA, Maria, PRAT, Núria, SOETEKOUW, Robert, VALL MAYANS, Martí, BAND, Caterina, CARCELES PEIRÓ, Victor, GALLARDO, Mireia, CASARES GONZALEZ, Pablo, GALVAN FEMENIA, Ivan, COMAS LEON, Xavier, MILLAT MARTÍNEZ, Pere, BASSAT ORELLANA, Quique, GARCIA, Nadia, GONZÁLEZ, María isabel, ANCOCHEA, Àgueda, GRÍFOLS, Joan ramon, VERDAGUER, Joaquim, ROQUER LÓPEZ, Clàudia, CONTRERAS, Enric, GIMÉNEZ, Montserrat, ARCOS VILA, Gemma, OUCHI, Dan, BLANCO GUILLERMO, Ignacio, VÉRTIZ GUIDOTTI, Thatiana, BONET PAPELL, Glòria, DASTIS ARIAS, Macarena, DELGADO CAPEL, Maria, BRIONES ZAMBRANO, Ney nicanor, FERRER, Magí, VIDELA, Sebastià, GUDIOL GONZÁLEZ, Carlota, FERNÁNDEZ RIVAS, Gema, CoV-Early Study Group, GARCÍA, Yolanda, RUIZ COMELLAS, Anna, VONDEREN, Marit van, BIANCO, Andrea sofia, BRAVO, Anna, OTERO, Aurema, MILLAN, Anna, RUIBAL SUAREZ, Jose carlos, BENAVENT, Sergio, ZARAUZA PELLEJERO, Alvaro, LÍNIO, Rosa, MALCHAIR, Pierre, BARO, Bàrbara, ROCA FONT, Judit, CARRASCO MATOS, Katherine m., SAÜCH VALMAÑA, Glòria, VIDAL OBRADORS, Carla, KATSIKIS, Peter, CAPDEVILA JÁUREGUI, Mar, KOOPMANS, Marion, ARA, Jordi, COnV-ert Study Group, RODRÍGUEZ CODINA, Joana, HERNÁNDEZ, Luis, TARRES GARCÍA, Silvia, BLANCO, Ignacio, HERNÁNDEZ, Águeda, GONZÁLEZ SOLER, Victoria, CURRIU SABATÈS, Margarida, FORNOS, Miriam, CASAMITJANA, Natàlia, BORDOY, Antoni e., ALONSO, Eva, GROENEVELD, Geert, REUSKEN, Chantal, ZWET, Erik van, MIEDEMA, Jelle, MÜLLER, Yvonne, MARTINEZ, Núria, RAMÍREZ MORROS, Anna, BOGERS, Susanne, MAGLIO, Laura analía, AMADO SIMON, Rosa, COMELLAS FERNANDEZ, Laura, VIOZQUEZ MEYA, Maria, COSTES, Gèlia, PRADENAS SAAVEDRA, Edwards, FORCADA, Anna, GAMMEREN, Adriaan van, GINNEKEN, Betty van, HARVALA, Heli, ZWAGINGA, Lisa, MARFIL, Silvia, TROXEL, Andrea, MOOIJAART, Simon, TRINITÉ, Benjamin, SAN JOSÉ, Alba, PICCOLO FERREIRA, Francini, BONET, Mireia, BLANCO, Julian, CANTONI, Jordi, RUSSCHER, Henk, MARKS, Michael, OUD, Josine, ZWAGINGA, Jaap jan, TORRANO SOLER, Pamela, MITJÀ VILLAR, Oriol, RIJNDERS, Bart j. a., DROOG, José de, FERRER, Susana, ALEMANY ORTIZ, Andrea, CORBACHO MONNÉ, Marc, SCHERPENISSE, Cees, HOLLANDER, Jan den, GHARBHARAN, Arvind, MEIER, Romy, ROKX, Casper, JORDANS, Carlijn, GEURTSVANKESSEL, Corine, ALBERSEN, Arjan, PAPAGEOURGIOU, Grigorios, PUIG, Jordi, ENGEN, Rene van, KARISLI, Ayten, GÖTZ, Hannelore, STRUIK, Jelle, DÍEZ SÁNCHEZ, Beatriz, GONZÁLEZ BEIRAS, Camila, PARÍS, Alexa, SUÑER NAVARRO, Clara, CLOTET, Bonaventura, REIMERINK, Johan, MAAS, Nanda, ROKX-NIEMANTSVERDRIET, Lotte, RODRIGUEZ ARIAS, Miquel angel, JIMÉNEZ, Zahida, VERSTIJNEN, Jose, GELOVEN, Nan van, SWANEVELD, Francis, RAMÍREZ VIAPLANA, Ferran, SCHOOT, Ellen van der, VRIELINK, Hans, LLOPIS ROCA, Ferran, GONZALEZ RUIZ, Cristian, FLORES AGUILERA, Begoña, VIVERO LARRAZA, Ainhoa, PONS BARBER, Maria, WATERING, Leo van de, HOGEMA, Boris, GONZÁLEZ GARCÍA, David, WIJNGAARDEN, Peter van, VIDAL ALABALL, Josep, ETTEN, Ronald van, BERG – RAHMAN, Juliette van der, KARIM, Faiz, HIDDEMA, Siepke, ELST, Kim van, NIETO RODRÍGUEZ, Raquel, GARCÍA GARCÍA, Vanesa, CASAÑ LOPEZ, Cristina, RODRIGUEZ CORTEZ, Orlando, LEEUWEN-SEGARCEANU, Elena van, NIETO, Aroa, RODRÍGUEZ SEVILLA, Graciela, REITSMA, Annette, NAVARRETE GONZALEZ, Laura, MOLENKAMP, Karin. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients. _Nature Communications_. 2022. Vol. 13, núm. 1. [consulta: 23 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/187056]