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2015-01-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/141814

Deregulation of purine metabolism in Alzheimer's disease

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Recurs relacionat

https://doi.org/10.1016/j.neurobiolaging.2014.08.004

Resum

The neuroprotective role of adenosine and the deregulation of adenosine receptors in Alzheimer's disease (AD) have been extensively studied in recent years. However, little is known about the involvement of purine metabolism in AD. We started by analyzing gene expression in the entorhinal cortex of human controls and AD cases with whole-transcript expression arrays. Once we identified deregulation of the cluster purine metabolism, messenger RNA expression levels of 23 purine metabolism genes were analyzed with qRT-PCR in the entorhinal cortex, frontal cortex area 8, and precuneus at stages I-II, III-IV, and V-VI of Braak and Braak and controls. APRT, DGUOK, POLR3B, ENTPD3, AK5, NME1, NME3, NME5, NME7, and ENTPD2 messenger RNAs were deregulated, with regional variations, in AD cases when compared with controls. In addition, liquid chromatography mass spectrometry based metabolomics in the entorhinal cortex identified altered levels of dGMP, glycine, xanthosine, inosine diphosphate, guanine, and deoxyguanosine, all implicated in this pathway. Our results indicate stage- and region-dependent deregulation of purine metabolism in AD.

Matèries

Malaltia d'Alzheimer, Metabolisme, Expressió gènica, Genètica, Purins, RNA

Matèries (anglès)

Alzheimer's disease, Metabolism, Gene expression, Genetics, Liquid farm manure, RNA

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Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

ANSOLEAGA, Belén, et al. Deregulation of purine metabolism in Alzheimer's disease. Neurobiology of Aging. 2015. Vol. 36, num. 1, pags. 68-80. ISSN 0197-4580. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/141814

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