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Published version

Publication date

2023-01-20

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cc by (c) García Segura, Pol et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/220672

STAT3 and REDD1: an unconventional story of gene repression

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https://doi.org/10.1111/febs.16727

Abstract

The non-canonical functions of the transcription factor STAT3 have been poorly studied in comparison to its canonical mechanisms of gene expression activation. Here, Köhler et al. put the spotlight on a novel unconventional repressing mechanism of STAT3 over the REDD1 gene, named DDIT4. These findings are crucial to expand the knowledge of the stress-induced short-lived REDD1 protein that inactivates mTOR and the consequences of this fine-tuned regulation in the context of pathological conditions such as cancer or neurodegenerative diseases.

Subject

Expressió gènica, Proteïnes, Cèl·lules immunocompetents

Subject (English)

Gene expression, Proteins, Immunocompetent cells

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citation

GARCÍA SEGURA, Pol and MALAGELADA GRAU, Cristina. STAT3 and REDD1: an unconventional story of gene repression. The FEBS Journal. 2023. Vol. 290, num. 7, pags. 1735-1739. ISSN 1742-464X. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/220672

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