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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/189350
Prosthetic shoulder joint infection by Cutibacterium acnes: does rifampin improve prognosis? a retrospective, multicenter, observational study.
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This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes-related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes-related PJI (median age, 67.5 years (IQR, 57.3-75.8)); 75% were men. The majority (61.4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43.2%) included β-lactam. Thirty-four patients (87.17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6.89; 95% CI: 0.80-58.90) or prior surgery and infection (OR: 10.67; 95% IC: 1.08-105.28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40.0% vs. 8.8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI.
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VILCHEZ, Helem h., ESCUDERO SÁNCHEZ, Rosa, FERNANDEZ-SAMPEDRO, Marta, MURILLO RUBIO, Óscar, AUÑÓN, Álvaro, RODRÍGUEZ-PARDO, Dolors, JOVER-SÁENZ, Alfredo, DEL TORO, Maria dolores, RICO, Alicia, FALGUERAS, Luis, PRAENA SEGOVIA, Julia, GUÍO, Laura, IRIBARREN, José a., LORA-TAMAYO MORILLO-VELARDE, Jaime, BENITO HERNÁNDEZ, M. natividad de, MORATA, Laura, RAMIREZ, Antonio, RIERA, Melchor. Prosthetic shoulder joint infection by Cutibacterium acnes: does rifampin improve prognosis? a retrospective, multicenter, observational study.. _Antibiotics_. 2021. Vol. 10, núm. 5. [consulta: 23 de gener de 2026]. ISSN: 2079-6382. [Disponible a: https://hdl.handle.net/2445/189350]