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Intl Journal of Cancer - 2023 - Palomar‐Cros.pdf (2.1 MB)

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2023-06-16

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cc by-nc (c) Palomar Cros, Anna et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/202622

Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

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https://doi.org/10.1002/ijc.34577

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Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers ( third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR=1.58, 95% CI 1.05-2.41, P trend=.03) and stomach cancer (OR=2.27 [0.99-5.44], P trend=.06). High consumption of aspartame, was associated with stomach cancer (OR=2.04 [0.7-5.4], P trend=.05), while a lower risk was observed for breast cancer (OR=0.28 [0.08-0.83], P trend=.03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.

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Edulcorants sintètics, Càncer

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Nonnutritive sweetener, Cancer

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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PALOMAR CROS, Anna, STRAIF, Kurt, ROMAGUERA, Dora, ARAGONÉS, Nuria, CASTAÑO VINYALS, Gemma, MARTÍN, Vicente, MORENO AGUADO, Víctor, GÓMEZ ACEBO, Inés, GUEVARA, Marcela, AIZPURUA, Amaia, MOLINA BARCELÓ, Ana, JIMÉNEZ MOLEÓN, José juan, TARDÓN, Adonina, CONTRERAS LLANES, Manuel, MARCOS GRAGERA, Rafael, HUERTA CASTAÑO, José maría, PÉREZ GÓMEZ, Beatriz, ESPINOSA, Ana, HERNÁNDEZ SEGURA, Natalia, OBÓN SANTACANA, Mireia, ALONSO MOLERO, Jessica, BURGUI, Rosana, AMIANO, Pilar, PINTO CARBÓ, Marina, OLMEDO REQUENA, Rocío, FERNÁNDEZ TARDÓN, Guillermo, SANTOS SÁNCHEZ, Vanessa, FERNÁNDEZ DE LARREA BAZ, Nerea, FERNÁNDEZ VILLA, Tania, CASABONNE, Delphine, DIERSSEN SOTOS, Trinidad, ARDANAZ, Eva, DORRONSORO, Ane, POLLÁN, Marina, KOGEVINAS, Manolis, LASSALE, Camille. Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain). _International Journal of Cancer_. 2023. Vol. 153, núm. 5, pàgs. 979-993. [consulta: 21 de gener de 2026]. ISSN: 1097-0215. [Disponible a: https://hdl.handle.net/2445/202622]

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