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2015-11

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/127368

The consensus molecular subtypes of colorectal cancer

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Recurs relacionat

https://doi.org/10.1038/nm.3967

Resum

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features: CMS1 (microsatellite instability immune, 14%), hypermutated, microsatellite unstable and strong immune activation; CMS2 (canonical, 37%), epithelial, marked WNT and MYC signaling activation; CMS3 (metabolic, 13%), epithelial and evident metabolic dysregulation; and CMS4 (mesenchymal, 23%), prominent transforming growth factor-beta activation, stromal invasion and angiogenesis. Samples with mixed features (13%) possibly represent a transition phenotype or intratumoral heterogeneity. We consider the CMS groups the most robust classification system currently available for CRC-with clear biological interpretability-and the basis for future clinical stratification and subtype-based targeted interventions.

Matèries

Càncer colorectal, Classificació de tumors, Oncologia

Matèries (anglès)

Colorectal cancer, Tumors classification, Oncology

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
<b>Publicacions de projectes de recerca finançats per la UE</b>
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

GUINNEY, Justin, DIENSTMANN, Rodrigo, WANG, Xin, REYNIÈS, Aurélien de, SCHLICKER, Andreas, SONESON, Charlotte, MARISA, Laetitia, ROEPMAN, Paul, NYAMUNDANDA, Gift, ANGELINO, Paolo, BOT, Brian m., MORRIS, Jeffrey, SIMON, Iris m., GERSTER, Sarah, FESSLER, Evelyn, SOUSA E MELO, Felipe de, MISSIAGLIA, Edoardo, RAMAY, Hena, BARRAS, David, HOMICSKO, Krisztian, MARU, Dipen, MANYAM, Ganiraju c., BROOM, Bradley, BOIGE, Valerie, PÉREZ VILLAMIL, Beatriz, LADERAS, Ted, SALAZAR SOLER, Ramón, GRAY, Joe w., HANAHAN, Douglas, TABERNERO CATURLA, Josep, BERNARDS, René, FRIEND, Stephen h., LAURENT PUIG, Pierre, MEDEMA, Jan paul, SADANANDAM, Anguraj, WESSELS, Lodewyk f. a., DELORENZI, Mauro, KOPETZ, Scott, VERMEULEN, Louis, TEJPAR, Sabine. The consensus molecular subtypes of colorectal cancer. _Nature Medicine_. 2015. Vol. 21, núm. 11, pàgs. 1350-1356. [consulta: 14 de gener de 2026]. ISSN: 1078-8956. [Disponible a: https://hdl.handle.net/2445/127368]

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