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2007

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/48634

Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions

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Abstract

A double side-reaction, consisting in the formation of Fmoc--Ala-OH and Fmoc--Ala-AA-OH, during the preparation of Fmoc protected amino acids (Fmoc-AA-OH) with Fmoc-OSu is discussed. Furthermore, the new Fmoc-2-MBT reagent is proposed for avoiding these side-reactions as well as the formation of the Fmoc-dipeptides (Fmoc-AA-AA-OH) and even tripeptides, which is another important side-reaction when chloroformates such as Fmoc-Cl is used for the protection of the -amino function of the amino acids.

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Reaccions químiques, Síntesi de pèptids

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Chemical reactions, Peptide synthesis

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

ISIDRO LLOBET, Albert, et al. Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions. Biopolymers. 2007. Vol. 88, num. 5, pags. 733-737. ISSN 0006-3525. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/48634

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