Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions

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dc.contributor.authorIsidro Llobet, Albert
dc.contributor.authorJust Baringo, Xavier
dc.contributor.authorEwenson, Ariel
dc.contributor.authorÁlvarez Domingo, Mercedes
dc.contributor.authorAlbericio Palomera, Fernando
dc.date.accessioned2013-12-20T12:30:39Z
dc.date.available2013-12-20T12:30:39Z
dc.date.issued2007
dc.date.updated2013-12-20T12:30:40Z
dc.description.abstractA double side-reaction, consisting in the formation of Fmoc--Ala-OH and Fmoc--Ala-AA-OH, during the preparation of Fmoc protected amino acids (Fmoc-AA-OH) with Fmoc-OSu is discussed. Furthermore, the new Fmoc-2-MBT reagent is proposed for avoiding these side-reactions as well as the formation of the Fmoc-dipeptides (Fmoc-AA-AA-OH) and even tripeptides, which is another important side-reaction when chloroformates such as Fmoc-Cl is used for the protection of the -amino function of the amino acids.
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec549100
dc.identifier.issn0006-3525
dc.identifier.urihttps://hdl.handle.net/2445/48634
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofBiopolymers, 2007, vol. 88, num. 5, p. 733-737
dc.rights(c) Wiley, 2007
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationReaccions químiques
dc.subject.classificationSíntesi de pèptids
dc.subject.otherChemical reactions
dc.subject.otherPeptide synthesis
dc.titleFmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/submittedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)