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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176918
Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections
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Staphylococcus saprophyticus is a primary cause of community-acquired urinary tract infections (UTIs) in young women. S. saprophyticus colonizes humans and animals but basic features of its molecular epidemiology are undetermined. We conducted a phylogenomic analysis of 321 S. saprophyticus isolates collected from human UTIs worldwide during 1997-2017 and 232 isolates from human UTIs and the pig-processing chain in a confined region during 2016-2017. We found epidemiologic and genomic evidence that the meat-production chain is a major source of S. saprophyticus causing human UTIs; human microbiota is another possible origin. Pathogenic S. saprophyticus belonged to 2 lineages with distinctive generic features that are globally and locally disseminated. Pangenome-wide approaches identified a strong association between pathogenicity and antimicrobial resistance, phages, platelet binding proteins, and an increased recombination rate. Our study provides insight into the origin, transmission, and population structure of pathogenic S. saprophyticus and identifies putative new virulence factors.
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LAWAL, Opeyemi u., FRAQUEZA, Maria j., BOUCHAMI, Ons, WORNING, Peder, BARTELS, Mette d., GONÇALVES, Maria l., PAIXAO, Paulo, GONÇALVES, Elsa, TOSCANO, Cristina, EMPEL, Joanna, URBÁS, Malgorzata, DOMÍNGUEZ LUZÓN, Ma. ángeles (maría ángeles), WESTH, Henrik, LENCASTRE, Hermínia de, MIRAGAIA, María. Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections. _Emerging Infectious Diseases_. 2021. Vol. 27, núm. 3, pàgs. 880-893. [consulta: 24 de gener de 2026]. ISSN: 1080-6040. [Disponible a: https://hdl.handle.net/2445/176918]