Miniatura

Fitxers

div-class-title-association-between-inflammation-and-neural-plasticity-biomarkers-in-olfactory-neuroepithelium-derived-cells-and-cognitive-performance-in-patients-with-major-depressive-disorder-div (1).pdf (39.8 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2022-06-01

Llicència de publicació

cc by (c) Toll, A. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/216323

Association between inflammation and neural plasticity biomarkers in olfactory neuroepithelium – derived cells and cognitive performance in patients with major depressive disorder

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1192/j.eurpsy.2022.1413

Resum

Introduction: Inflammation and neural plasticity play a significant role in major depressive disorder (MDD) pathogenesis and cognitive dysfunction. The olfactory neuroepithelium (ON), closely related to the central nervous system (CNS), allows a non-invasive, low-cost study of neuropsychiatric disorders. However, few studies have used ON cells to ascertain them as biomarkers for MDD. Objectives: Determine the relationship between inflammatory/neural plasticity markers and cognitive functioning in MDD patients and healthy controls. Methods: Sample: 9 MDD patients and 7 healthy controls. Exclusion criteria: other Axis I mental disorders (patients) or any mental disorder (controls) and any inflammatory, autoimmune, or CNS diseases. Assessment: sociodemographic, clinical, and cognitive variables (CANTAB) were recorded. mRNA was isolated from ON cells and MAPK14, IL6, TNF-α, Mecp2, BDNF, GSK3, GRIA2, and FosB gene expression levels were quantified using quantitative polymerase chain reaction. Results: MDD patients showed decreased levels of BDNF (p=0.022), GSK3 (p=0.027), and working memory (p=0.024) compared with healthy controls. In healthy controls, planning was positively correlated with NRF2, BDNF, and MAPK14 gene expression. In MDD patients no correlation between cognitive parameters and inflammation/neural plasticity biomarkers was found. Conclusions: These results reveal that: (1) Plasticity biomarkers such as BDNF and GSK3 could be useful diagnostic tools for MDD (2) MDD is associated with working memory deficits; (3) no association could be determined between planning and NRF2, BDNF, and MAPK14 gene expression in MDD and (4) the ON is a promising model in the study of neuropsychiatric disorders.

Matèries

Depressió psíquica, Inflamació

Matèries (anglès)

Mental depression, Inflammation

Citació

Col·leccions

Comunicacions a congressos (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

TOLL, A., PORTELLA, M., ROBLEDO, P., BARRERA CONDE, M., DE LA TORRE, R., GINÉS, J.m., DIEZ AJA, C., SORIA, Virginia, LÓPEZ GARCÍA, Pilar, PÉREZ SOLÀ, V., ALVAREZ, P.. Association between inflammation and neural plasticity biomarkers in olfactory neuroepithelium – derived cells and cognitive performance in patients with major depressive disorder. _European Psychiatry_. 2022. Vol. 65, núm. 1, pàgs. 552. [consulta: 24 de gener de 2026]. ISSN: 1778-3585. [Disponible a: https://hdl.handle.net/2445/216323]

Exportar metadades

JSON - METS

Compartir registre