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div-class-title-association-between-inflammation-and-neural-plasticity-biomarkers-in-olfactory-neuroepithelium-derived-cells-and-cognitive-performance-in-patients-with-major-depressive-disorder-div (1).pdf (39.8 KB)

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2022-06-01

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cc by (c) Toll, A. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/216323

Association between inflammation and neural plasticity biomarkers in olfactory neuroepithelium – derived cells and cognitive performance in patients with major depressive disorder

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Recurs relacionat

https://doi.org/10.1192/j.eurpsy.2022.1413

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Introduction: Inflammation and neural plasticity play a significant role in major depressive disorder (MDD) pathogenesis and cognitive dysfunction. The olfactory neuroepithelium (ON), closely related to the central nervous system (CNS), allows a non-invasive, low-cost study of neuropsychiatric disorders. However, few studies have used ON cells to ascertain them as biomarkers for MDD. Objectives: Determine the relationship between inflammatory/neural plasticity markers and cognitive functioning in MDD patients and healthy controls. Methods: Sample: 9 MDD patients and 7 healthy controls. Exclusion criteria: other Axis I mental disorders (patients) or any mental disorder (controls) and any inflammatory, autoimmune, or CNS diseases. Assessment: sociodemographic, clinical, and cognitive variables (CANTAB) were recorded. mRNA was isolated from ON cells and MAPK14, IL6, TNF-α, Mecp2, BDNF, GSK3, GRIA2, and FosB gene expression levels were quantified using quantitative polymerase chain reaction. Results: MDD patients showed decreased levels of BDNF (p=0.022), GSK3 (p=0.027), and working memory (p=0.024) compared with healthy controls. In healthy controls, planning was positively correlated with NRF2, BDNF, and MAPK14 gene expression. In MDD patients no correlation between cognitive parameters and inflammation/neural plasticity biomarkers was found. Conclusions: These results reveal that: (1) Plasticity biomarkers such as BDNF and GSK3 could be useful diagnostic tools for MDD (2) MDD is associated with working memory deficits; (3) no association could be determined between planning and NRF2, BDNF, and MAPK14 gene expression in MDD and (4) the ON is a promising model in the study of neuropsychiatric disorders.

Matèries

Depressió psíquica, Inflamació

Matèries (anglès)

Mental depression, Inflammation

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Comunicacions a congressos (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

TOLL, A., et al. Association between inflammation and neural plasticity biomarkers in olfactory neuroepithelium – derived cells and cognitive performance in patients with major depressive disorder. European Psychiatry. 2022. Vol. 65, num. 1, pags. 552. ISSN 1778-3585. [consulted: 27 of May of 2026]. Available at: https://hdl.handle.net/2445/216323

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