Comunicacions a congressos (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)
(IMR Press, 2026-01-21) Fernández, Óscar; Arés, Adrián; Agüera, Eduardo; Aladro, Yolanda; Alonso, Ana; Arroyo, Rafael; Brieva, Luis; Calles, Carmen; Caminero, Ana Belén; Castillo Triviño, Tamara ; Costa Frossard, Lucienne; Eichau, Sara; Hernández, Miguel Ángel; Landete, Lamberto; Llaneza, Miguel; Llufriu, Sara; Meca Lallana, José E. ; Meca Lallana, Virginia ; Moral, Ester; Oreja Guevara, Celia; María Prieto, José; Romero Pinel, Lucía María ; Vilaseca, Andreu; Rodríguez Antiguedad, Alfredo
Introduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists specialized in multiple sclerosis (MS), who presented a summary of the most relevant advances discussed at the ECTRIMS congress, held days before in Copenhagen. Aim: To present new developments in neurodegeneration and progression, the prodromal phase and diagnosis, the clinical use of biomarkers and neuroimaging, as well as the current role of patient-reported outcomes and digital monitoring. Highlights on the risk of infections and comorbidities in MS are also summarized. Content and Conclusions: In active MS lesions, there is no correlation between the myeloid cell phenotype and remyelination, while memory astrocytes, regulated by the CLEC16A gene, are present in chronic active lesions. Gray matter atrophy is associated with disability and progression independent of relapses, whereas cervical spinal cord atrophy predicts the prognosis of progressive forms and may lead to earlier diagnosis. Healthcare resource utilization increases in the years preceding the first demyelinating event, and although prodromal symptoms are highly variable, they are useful in identifying risk factors for the disease. The new McDonald criteria will facilitate the diagnosis of MS in patients with a radiologically isolated syndrome. Glial fibrillary acidic protein complements neurofilaments, and both biomarkers could soon be standardized for use in clinical practice; paramagnetic rim lesions and slowly expanding lesions are promising imaging markers. In another area, patient-reported health outcomes are valuable, although they are subject to selection bias and the need to define boundaries for their use. Finally, the risk of infections increases before diagnosis and may worsen with certain treatments. Comorbidities in MS should be managed as an integral part of disease management.
XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (II)
(IMR Press, 2026-01-21) Fernández, Óscar; Arés, Adrián; Agüera, Eduardo; Aladro, Yolanda; Alonso, Ana; Arroyo, Rafael; Brieva, Luis; Calles, Carmen; Belén Caminero, Ana; Castillo Triviño, Tamara ; Costa Frossard, Lucienne ; Eichau, Sara; Ángel Hernández, Miguel; Landete, Lamberto; Llaneza, Miguel; Llufriu, Sara; Meca Lallana, José E. ; Meca Lallana, Virginia ; Moral, Ester; Oreja Guevara, Celia ; María Prieto, José; Romero Pinel, Lucía María ; Vilaseca, Andreu; Rodríguez Antiguedad, Alfredo
Introduction: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists specialized in multiple sclerosis (MS), who presented a summary of the most relevant advances discussed at the ECTRIMS congress, held days before in Copenhagen.Aim: To summarize the main new findings in clinical research on MS.Content and Conclusions: The immunological changes throughout life and in response to MS treatments were analyzed. The impact of aging was also discussed, along with new developments related to symptomatic treatments, physical exercise, fatigue, and sleep disorders. Emphasis was placed on addressing ongoing challenges in measuring therapeutic failure and managing treatments for secondary progressive MS. Additionally, data from registries and real-world studies were presented, including new analyses on cladribine, highlighting the need to collect safety information. Regarding immune reconstitution therapies, mechanisms of action and the immune system's reconstitution process after treatment were explored. Finally, regarding therapeutic innovations, the first results from chimeric antigen receptor (CAR)-T cell therapy studies in MS were reported, representing a promising advancement in disease management.
Developmental trajectories of gambling severity after cognitive-behavioral therapy
(Royal College of Psychiatrists, 2022-09-01) Jiménez-Murcia, Susana; Granero, Roser; Fernández Aranda, Fernando
To estimate trajectories of the gambling disorder (GD) severity for 12 months following a manualized cognitive-behavior-therapy (CBT) program, and to identify the main variables associated with each trajectory.
Predictors of Therapy Outcome in Eating Disorders: from Psychopathology to Personality
(Royal College of Psychiatrists, 2022-09-01) Fernández Aranda, Fernando; Jiménez-Murcia, Susana; Granero, Roser
N/A
Neuropsychological functions as trait markers in OCD: a long term follow-up
(Royal College of Psychiatrists, 2022-09-01) Puialto Amieiro, Mar; Segalàs Cosi, Cinto
The present study aimed to examine neuropsychological patterns in OCD patients and several clinical variables before and after a follow-up of 10 years.
Renal progenitor cells an early non-invasive biomarker of silent kidney injury in Fabry disease
(Oxford University Press (OUP), 2024-05-01) Ugalde Altamirano, Jessica; Rovira Juárez, Jordi; Tubita, Valeria; Campistol Plana, Josep M.; Poch, Esteban; Diekmann, Fritz; Piñeiro, Gaston; Cucchiari, David; Azorin, Sebastian; Bañón Maneus, Elisenda; Corral Velez, Vicente; Torregrosa Prats, José Vicente
Fabry's disease (FD), a hereditary condition, is linked to the X chromosome due to a mutation in the gene encoding alpha-galactosidase A (alpha-GalA).
Oncological safety of fertility preservation treatment in ovarian cancer
(BMJ Publishing Group Ltd, 2023-09-01) Heras, Marta; Azcona, Leticia; Arencibia, Octavio; Minig, Lucas; Martí, Lola; Hernandez, Alicia; Lekuona, Arantxa; Ñiguez, Isabel; Gil Ibáñez, Blanca; Díaz Feijoo, Berta; Ribot, Laia; Cabezas, Maria Nieves; Lamarca, Marta; Bellón, Mónica; Alkourdi, Amira; Cárdenas, Laura; Boldo, Ana; Amengual, Joana; Gorostidi, Mikel; Zapardiel, Ignacio
To assess the safety of fertility sparing treatments for early-stage ovarian cancer in women younger than 45 years.
Reproductive outcomes after fertility sparing surgery for ovarian cancer
(BMJ Publishing Group Ltd, 2023-09-01) Heras, Marta; Alonso Espías, María; Arencibia, Octavio; Minig, Lucas; Martí, Lola; Diestro, Maria Dolores; Céspedes, Juan; Ñiguez, Isabel; Gil Ibáñez, Blanca; Díaz Feijoo, Berta; Llueca, Antoni; Rosado, Claudia; Iacoponi, Sara; Manzanara, Carlos López De La; Morales, Sara; Fernández Galguera, Maria José; Alcalá, Maria Del Mar; Cano, Ana; Gorostidi, Mikel; Zapardiel, Ignacio
To prove the effectivity of fertility sparing procedures in young patients with ovarian cancer at early stage by assessing the pregnancy rates and obstetrical outcomes.
Magnetic resonance imaging or expert ultrasound in preoperative local staging of patients with early-stage cervical cancer: final results of the SENTIX prospective, single-arm, international trial (CEEGOG CX-01; ENGOT-CX2)
(BMJ Publishing Group Ltd, 2023-09-01) Kocián, Roman; Siegler, Kathrin; Klát, Jaroslav; Benešová, Klára; Paderno, Mariachiara; Lonkhuijzen, Luc Van; Chaloupková, Barbora; Pilka, Radovan; Michal, Martin; Kašcák, Peter; Kridelka, Frédéric; Pakiž, Maja; Snyman, Leon Cornelius; Barahona, Marc; Sawicki, Sambor; Blecharz, Pawel; Redecha, Mikuláš; Tóth, Róbert; Cibula, David; Köhler, Christhardt
SENTIX is a prospective, single-arm, international study of sentinel lymph node (SLN) biopsy without pelvic lymph node dissection (PLND) in patients with early-stage cervical cancer.
Treatment of low-risk endometrial cancer: evaluation of results after sentinel node biopsy
(BMJ Publishing Group Ltd, 2023-09-01) Veiga, Nadia; Martí, Lola; Fernández, Sergi; Barahona, Marc; Ponce, Jordi
Since application of sentinel lymph node (SLN) technique in low-risk endometrial tumors, the procedure for performing the lymph node assessment has
ETMR-30. Clinical and molecular characterization of dicer-mutant central nervous system sarcoma
(Oxford University Press (OUP), 2024-06-18) Dowiak, Alexis; Williamson, Lane; Povilaikaite, Julija; Cabrera, Edgar; Aponte, Nelson; Garcia, Johnny; Quiroz, Lina; Piña, Martha; Martinez, Cindy; Valencia, Diana; Barragan, Liliana; Benito Reséndiz, Alma; Magelssen, Henriette; Trujillo, Ángela; Osorio, Diana; Figueredo, Oscar; Packer, Roger; Sarmiento, Isabel; Suarez, Amaranto; Mushtaq, Naureen; Abdullaev, Zied; Poria, Dipak; Bartels, Ute; Bouffett, Eric; Rivera Polo, Barbara; Aldape, Kenneth; Ramaswamy, Vijay; Fonseca, Adriana
Central nervous system (CNS) sarcomas are rare mesenchymal non-meningothelial tumors accounting for 0.2% of brain tumors. Due to their rarity, there is a lack of substantive clinical, histological and molecular data.
Prognostic factors among young women with epithelial ovarian cancer: the YOC-care study (young ovarian cancer – care)
(BMJ Publishing Group Ltd, 2023-09-01) Azcona Sutil, Leticia; Heras, Marta; Arencibia, Octavio; Minig, Lucas; Marti, Maria Dolores; Baciu, Andrea; Cespedes, Juan; Ñiguez, Isabel; Gil Ibáñez, Blanca; Díaz Feijoo, Berta; Melero Cortes, Lidia Maria; Marcos, Josefina; Garcia Villayzan, Jose; Gomez, Benjamina; Montesinos, Manel; Herrero, Sofia; Gilabert Estellés, Juan; Fernandez Chereguini, Maria; Gorostidi, Mikel; Zapardiel, Ignacio
Ovarian cancer is the most lethal of all gynaecological neoplasms in young women, affecting up to 10–15% of premenopausal women, however, there is very limited data on which are the most important prognostic factors
Surgical planification of 3D reconstruction with robotic partial cystectomy and colpectomy for cervical cancer recurrence
(BMJ Publishing Group, 2023-09-01) Fernández González, Sergi; Torrejon, Juan Carlos; Barahona, Marc; Muñoz, Ana Maria; Perez, Yolanda; Buisan, Oscar; Martí, Lola; Ponce, Jordi
Surgery is the only curative treatment in case of localized recurrence of cervical cancer in patients who had been treated with previous radiotherapy
Neuropsychological functions as endophenotype markers in ocd: a long term follow-up
(Cambridge University Press, 2024-04-01) Puialto Amieiro, Mar; Segalàs Cosi, Cinto; Alonso Ortega, María del Pino; Real Barrero, Eva
The present study aimed to study what kind of cognitive deficits OCD patients have and how aging and clinical course modify their cognitive profiles campared with general population
Introducing the construct of risky cannabis use: designing and piloting a co-created educational intervention on cannabis health literacy among adolescents and young adults. The CAHLY (CAnabis Health LiteracY) study.
(Cambridge University Press, 2024-04-01) Caballeria, E.; Oliveras, Clara; Guzmán, P.; Ballbè i Gibernau, Montse; Fleur, B.; Pol, B.; Ilzarbe, D.; López Pelayo, Hugo; Matrai, S.; Artigas, M.; Pons-Cabrera, Maria Teresa; Folch, D.; Nuño, L.; Balcells Oliveró, Maria Mercè
Cannabis use poses a significant risk to the psychological wellbeing of youth, affecting academic performance and potentially triggering the onset of mental health issues. Providing young people with comprehensive information about patterns of cannabis useandspecific factorsthatincrease anindividual’shealth risks is crucial. The ability to critically assimilate this information is known as health literacy (HL).
Desensitization techniques in ABO-incompatible renal transplantation: efficacy and analysis of complications
(Oxford University Press (OUP), 2024-05-01) Vega González, Silvia; Toledo Jara, Michele; Alvarez Esteban, Rafael; Hueso Val, Miguel; Rodriguez Urquia, Ronny Isaac; Quero Ramos, Maria; Coloma, Ana; Manonelles, Anna; Couceiro, Carlos; Rama, Inés; Cruzado, Josep Ma.; Sandoval, Diego
Living donor transplantation is the best optimal choice for the vast majority of patients with terminal renal insufficiency. However, it is limited by the AB0/ HLA incompatibility between donor and receptor. The resolution of this inconvenient relies on desensitization of isoagglutinins (anti-AB0 immunoglobulins depletion); thus transplantation could be performed safely.
Therapeutic apheresis in Fabry disease
(Oxford University Press (OUP), 2024-05-01) Ugalde Altamirano, Jessica; Rovira Juárez, Jordi; Campistol Plana, Josep M.; Lozano, Miquel; Cid Vidal, Joan; Piñeiro, Gastón Julio; Ramírez Bajo, María José; Corral Velez, Vicente; Revuelta, Ignacio; Roca, Ramon; Calls, Jordi; Torregrosa Prats, José Vicente
Fabry’s disease (FD) is a rare lysosomal disorder linked to the X chromosome due to a mutation in the gene encoding alpha-galactosidase A (alpha-Gal A). This mutation leads to a defect in the metabolism of glycosphingolipids, causing the progressive accumulation of globotriaacylceramide (GB3) or LysoGB3 in cells, tissues, and organs. In the treatment of FD, we have enzyme replacement therapy (ERT) with Agalsidase-alfa (Replagal®), Agalsidase-beta (Fabrazyme®), and chaperones (Migalastat®). However, there are limitations such as disease progression and morbimortality.
Long-term renal outcomes in ICI-associated acute interstitial nephritis: a comprehensive comparative study
(Oxford University Press (OUP), 2024-05-01) Martinez Valenzuela, Laura; Lino, Luis; Gomez Preciado, Francisco; Fulladosa, Xavier; Cruzado, Josep Ma.; Torras Ambròs, Joan; Draibe, Juliana
Immune checkpoint inhibitors (ICI) have transformed cancer treatment, but they may lead to immune- mediated acute interstitial nephritis (ICI-AIN), in 2-5% of patients. About 35-40% show full kidney function recovery three months post ICI-AIN. Limited evidence exists for long-term renal toxicity.
Delayed initiation or reduced initial dose of calcineurin-inhibitors for kidney transplant recipients: a systematic review and meta-analysis
(Oxford University Press (OUP), 2024-05-01) Oliveras Pagès, Laia; Lopez Vargas, Pamela; Melilli, Edoardo; Codina, Sergi; Royuela, Ana; Coloma, Ana; Favà, Àlex; Manonelles, Anna; Lloberas Blanch, Núria; Couceiro, Carlos; Cruzado, Josep Ma.; Montero, Nuria
Delayed graft function (DGF) is more common in donors after cardiac death, especially expanded criteria donors and those with longer cold ischaemia time, older or with an increased serum creatinine. There is no agreement on the optimal immunosuppressive approach in patients at increased risk of DGF, with strategies including a delayed introduction of calcineurin inhibitors (CNI) or initial low dose CNI.
The role of sodium-glucose cotransporter 2 inhibitors in diabetic nephropathy and non diabetic renal disease in diabetes mellitus type 2 patients
(Oxford University Press (OUP), 2024-05-01) Ibernón, Meritxell; Navarro, Maru; Gomà, Montse ; Tango, Ariel; Rap, Oana; Cabrera, Cristina; Sánchez, Ana; Rodriguez, Neus; Ruiz, Pilar
Diabetes Mellitus type 2 (DM2) leads to chronic kidney disease in a 30-40% of diabetic patients and it is the major cause of end stage renal disease (ESRD). The clinical course of diabetic kidney disease is very heterogeneous and there is a lack of agreement between clinical parameters and renal histology. Besides, lesions of non-diabetic kidney disease (NDRD) can coexist with lesions of diabetic nephropathy (DN) in two-thirds of kidney biopsies in patients with diabetes.

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