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Article

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2019-01-10

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cc-by (c) Rigo-Adrover, Mar et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/130738

Rotavirus double infection model to study preventive dietary interventions

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https://doi.org/10.3390/nu11010131

Abstract

Rotaviruses are the main cause of acute diarrhea among young children worldwide with an increased frequency of reinfection. Several life style factors, such as dietary components, may influence such processes by affecting the outcome of the first rotavirus infection and therefore having a beneficial impact on the anti-rotavirus immune responses during any subsequent reinfections. The aim of this research was to develop a double-infection model in rat that mimics real-life clinical scenarios and would be useful in testing whether nutritional compounds can modulate the rotavirus-associated disease and immune response. Three experimental designs and a preventive dietary-like intervention were conducted in order to achieve a differential response in the double-infected animals compared to the single-infected ones and to study the potential action of a modulatory agent in early life. Diarrhea was only observed after the first infection, with a reduction of fecal pH and fever. After the second infection an increase in body temperature was also found. The immune response against the second infection was regulated by the preventive effect of the dietary-like intervention during the first infection in terms of specific antibodies and DTH. A rotavirus-double-infection rat model has been developed and is suitable for use in future preventive dietary intervention studies. KEYWORDS: diarrhea; double-infection; model; rat; rotavirus

Subject

Diarrea, Malalties inflamatòries intestinals, Malalties infeccioses en els infants

Subject (English)

Diarrhea, Inflammatory bowel diseases, Communicable diseases in children

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Articles publicats en revistes (Bioquímica i Fisiologia)

Citation

RIGO ADROVER, Maria del Mar, et al. Rotavirus double infection model to study preventive dietary interventions. Nutrients. 2019. Vol. 11, num. 1, pags. 131. ISSN 2072-6643. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/130738

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