Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

warrington2017_2725.pdf (1.43 MB)

Document type

Article

Version

Published version

Publication date

2017-10-09

Publication license

cc-by-nc-sa (c) Warrington et al., 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/117486

Maternal and fetal genetic contribution to gestational weight gain

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://dx.doi.org/10.1038/ijo.2017.248

Abstract

BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. PARTICIPANTS AND METHODS: A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (e.g. maternal BMI and glucose, birthweight). RESULTS: Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explaining variation in GWG. Variants near the Pregnancy Specific Beta-1-Glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 x 10-8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birthweight variants were largely unrelated to GWG. CONCLUSION: We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and later offspring/maternal outcomes may be due to the relationship of maternal BMI and diabetes with GWG.International Journal of Obesity accepted article preview online, 09 October 2017. doi:10.1038/ijo.2017.248.

Subject

Genètica mèdica, Pes corporal, Embaràs

Subject (English)

Medical genetics, Body weight, Pregnancy

Citation

Collections

Articles publicats en revistes (ISGlobal)

Citation

WARRINGTON, Nicole M., et al. Maternal and fetal genetic contribution to gestational weight
                gain. International Journal of Obesity. 2017. pags. Ahead
                of print. ISSN 0307-0565. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/117486

Export metadata

JSON - METS

Share record