Miniatura

Fitxers

632357.pdf (933.4 KB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2013-01-01

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126022

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/ng.2652

Resum

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.

Matèries

Leucèmia limfocítica crònica, Genòmica

Matèries (anglès)

Chronic lymphocytic leukemia, Genomics

Citació

Col·leccions

Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BERNDT, Sonja i., SKIBOLA, Christine f., JOSEPH, Vijai, CAMP, Nicola j., NIETERS, Alexandra, WANG, Zhaoming, COZEN, Wendy, MONNEREAU, Alain, WANG, Sophia s., KELLY, Rachel s., LAN, Qing, TERAS, Lauren r., CHATTERJEE, Nilanjan, CHUNG, Charles c., YEAGER, Meredith, BROOKS-WILSON, Angela r., HARTGE, Patricia, PURDUE, Mark p., BIRMANN, Brenda m., ARMSTRONG, Bruce k., COCCO, Pierluigi, ZHANG, Yawei, SEVERI, Gianluca, ZELENIUCH-JACQUOTTE, Anne, LAWRENCE, Charles, BURDETTE, Laurie, YUENGER, Jeffrey, HUTCHINSON, Amy, JACOBS, Kevin b., CALL, Timothy g., SHANAFELT, Tait d., NOVAK, Anne j., KAY, Neil e., LIEBOW, Mark, WANG, Alice h., SMEDBY, Karin e., ADAMI, Hans-olov, MELBYE, Mads, GLIMELIUS, Bengt, CHANG, Ellen t., GLENN, Martha, CURTIN, Karen, CANNON-ALBRIGHT, Lisa a., JONES, Brandt, DIVER, W. ryan, LINK, Brian k., WEINER, George j., CONDE, Lucía, BRACCI, Paige m., RIBY, Jacques, HOLLY, Elizabeth a., SMITH, Martyn t., JACKSON, Rebecca d. j., TINKER, Lesley f., BENAVENTE, Yolanda, BECKER, Nikolaus, BOFFETTA, Paolo, BRENNAN, Paul, FORETOVA, Lenka, MAYNADIÉ, Marc, MCKAY, James d., STAINES, Anthony. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. _Nature Genetics_. 2013. Vol. 8, núm. 45, pàgs. 868-876. [consulta: 21 de gener de 2026]. ISSN: 1061-4036. [Disponible a: https://hdl.handle.net/2445/126022]

Exportar metadades

JSON - METS

Compartir registre