Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/149464
Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The blood-brain barrier is a physical and physiological barrier that protects the brain from toxic substances within the bloodstream and helps maintain brain homeostasis. It also represents the main obstacle in the treatment of many diseases of the central nervous system. Among the different approaches employed to overcome this barrier, the use of nanoparticles as a tool to enhance delivery of therapeutic molecules to the brain is particularly promising. There is special interest in the use of magnetic nanoparticles, as their physical characteristics endow them with additional potentially useful properties. Following systemic administration, a magnetic field applied externally can mediate the capacity of magnetic nanoparticles to permeate the blood-brain barrier. Meanwhile, thermal energy released by magnetic nanoparticles under the influence of radiofrequency radiation can modulate blood-brain barrier integrity, increasing its permeability. In this review, we present the strategies that use magnetic nanoparticles, specifically iron oxide nanoparticles, to enhance drug delivery to the brain
Matèries
Matèries (anglès)
Citació
Citació
BUSQUETS I VIÑAS, Ma. antonia, ESPARGARÓ COLOMÉ, Alba, SABATÉ LAGUNAS, Raimon, ESTELRICH I LATRÀS, Joan. Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge. _Nanomaterials_. 2015. Vol. 5, núm. 2231-2248. [consulta: 21 de gener de 2026]. ISSN: 2079-4991. [Disponible a: https://hdl.handle.net/2445/149464]