Role of MITF in IgE and MRGPRX2-dependent mast cell activation

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dc.contributor.advisorMartín Andorrà, Margarita
dc.contributor.authorGuo, Yanru
dc.contributor.otherUniversitat de Barcelona. Departament de Biomedicina
dc.date.accessioned2025-09-19T07:31:11Z
dc.date.available2025-09-19T07:31:11Z
dc.date.issued2023-07-20
dc.description.abstract[eng] Anaphylaxis is a severe allergic reaction triggered by allergens to certain foods, medicines, insect venom, and other substances. Anaphylactic shock can be fatal if not treated. Mast cells are the effector cells in anaphylaxis, and mast cell transcriptional factors are crucial in controlling the production of mediators. In summary, this thesis shows the relevance of microphthalmia associatedtranscription factor (MITF) in IgE and MRGPRX2-dependent mast cell activation. Thus, MITF and MITF-dependent genes may become targets to treat IgE or MRGPRX2-dependent pathologies.ca
dc.format.extent158 p.
dc.format.mimetypeapplication/pdf
dc.identifier.tdxhttp://hdl.handle.net/10803/695239
dc.identifier.urihttps://hdl.handle.net/2445/223265
dc.language.isoengca
dc.publisherUniversitat de Barcelona
dc.rights(c) Guo, Yanru, 2023
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.sourceTesis Doctorals - Departament - Biomedicina
dc.subject.classificationImmunologia
dc.subject.classificationAl·lèrgia
dc.subject.classificationTransducció de senyal cel·lular
dc.subject.classificationAnafilaxi
dc.subject.otherImmunology
dc.subject.otherAllergy
dc.subject.otherCellular signal transduction
dc.subject.otherAnaphylaxis
dc.titleRole of MITF in IgE and MRGPRX2-dependent mast cell activationca
dc.typeinfo:eu-repo/semantics/doctoralThesisca
dc.typeinfo:eu-repo/semantics/publishedVersion

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Tesis Doctorals - Departament - Biomedicina