Miniatura

Fitxers

662570.pdf (3.17 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2014-08-12

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/106547

How many etiological subtypes of breast cancer: two, three, four, or more?

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1093/jnci/dju165

Resum

Breast cancer is a heterogeneous disease, divisible into a variable number of clinical subtypes. A fundamental question is how many etiological classes underlie the clinical spectrum of breast cancer? An etiological subtype reflects a grouping with a common set of causes, whereas a clinical subtype represents a grouping with similar prognosis and/or prediction. Herein, we review the evidence for breast cancer etiological heterogeneity. We then evaluate the etiological evidence with mRNA profiling data. A bimodal age distribution at diagnosis with peak frequencies near ages 50 and 70 years is a fundamental characteristic of breast cancer for important tumor features, clinical characteristics, risk factor profiles, and molecular subtypes. The bimodal peak frequencies at diagnosis divide breast cancer overall into a 'mixture' of two main components in varying proportions in different cancer populations. The first breast cancer tends to arise early in life with modal age-at-diagnosis near 50 years and generally behaves aggressively. The second breast cancer occurs later in life with modal age near 70 years and usually portends a more indolent clinical course. These epidemiological and molecular data are consistent with a two-component mixture model and compatible with a hierarchal view of breast cancers arising from two main cell types of origin. Notwithstanding the potential added value of more detailed categorizations for personalized breast cancer treatment, we suggest that the development of better criteria to identify the two proposed etiologic classes would advance breast cancer research and prevention.

Matèries

Càncer de mama, Etiologia

Matèries (anglès)

Breast cancer, Etiology

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

ANDERSON, William f., ROSENBERG, Philip s., PRAT APARICIO, Aleix, PEROU, Charles m., SHERMAN, Mark e.. How many etiological subtypes of breast cancer: two, three, four, or more?. _JNCI: Journal of The National Cancer Institute_. 2014. Vol. 106, núm. 8, pàgs. dju165. [consulta: 2 de febrer de 2026]. ISSN: 0027-8874. [Disponible a: https://hdl.handle.net/2445/106547]

Exportar metadades

JSON - METS

Compartir registre