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74991-300700-4-PB.pdf (254.3 KB)

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2021-07-06

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cc by-nc-nd (c) Via Medica, 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/179795

Long-term antibiotic therapy in patients with surgery-indicated not undergoing surgery infective endocarditis

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Recurs relacionat

https://doi.org/10.5603/CJ.a2021.0054

Resum

Background: To date, there is little information regarding management of patients with infective endocarditis (IE) that did not undergo an indicated surgery. Therefore, we aimed to evaluate prognosis of these patients treated with a long-term antibiotic treatment strategy, including oral long term suppressive antibiotic treatment in five referral centres with a multidisciplinary endocarditis team. Methods: This retrospective, multicenter study retrieved individual patient-level data from five referral centres in Spain. Among a total of 1797, 32 consecutive patients with IE were examined (median age 72 years; 78% males) who had not undergone an indicated surgery, but received long-term antibiotic treatment (LTAT) and were followed by a multidisciplinary endocarditis team, between 2011 and 2019. Primary outcomes were infection relapse and mortality during follow-up. Results: Among 32 patients, 21 had IE associated with prostheses. Of the latter, 8 had an ascending aorta prosthetic graft. In 24 patients, a switch to long-term oral suppressive antibiotic treatment (LOSAT) was considered. The median duration of LOSAT was 277 days. Four patients experienced a relapse during follow-up. One patient died within 60 days, and 12 patients died between 60 days and 3 years. However, only 4 deaths were related to IE. Conclusions: The present study results suggest that a LTAT strategy, including LOSAT, might be considered for patients with IE that cannot undergo an indicated surgery. After hospitalization, they should be followed by a multidisciplinary endocarditis team.

Matèries

Endocarditis, Antibiòtics, Cirurgia

Matèries (anglès)

Endocarditis, Antibiotics, Surgery

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

VALLEJO CAMAZON, Nuria, et al. Long-term antibiotic therapy in patients with surgery-indicated not undergoing surgery infective endocarditis. Cardiology Journal. 2021. Vol. 28, num. 4, pags. 566-578. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/179795

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