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Exuberant complex metaplastic carcinoma of the breast with sox2 expression: covering the full spectrum of ductal neoplasia of the breast

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dc.contributor.authorSagasta, Amaia
dc.contributor.authorSaco, Adela
dc.contributor.authorRodríguez-Carunchio, Leonardo
dc.contributor.authorRull Ortuño, Antonio Ramón
dc.contributor.authorRuiz, Ana
dc.contributor.authorCarrió, Ana
dc.contributor.authorFalcón Escobedo, Reynaldo
dc.contributor.authorFernández Ruiz, Pedro Luis
dc.date.accessioned2018-01-15T18:10:55Z
dc.date.available2018-01-15T18:10:55Z
dc.date.issued2014-11-21
dc.date.updated2018-01-15T18:10:55Z
dc.description.abstractWe report a unusual case of a 45-year-old woman with a massive metaplastic carcinoma of the breast with a complex admixture of components including giant pleomorphic cells, sarcomatoid areas, cysts with undifferentiated stratified epithelium, squamous carcinoma foci, high grade comedo-type ductal carcinoma in situ, high grade invasive carcinoma not otherwise specified (NOS) and foci with osseous differentiation. An extensive immunohistochemical panel showed expression of both epithelial and mesenchymal markers. The self-renewal marker SOX2 was expressed in different cell types, which was interpreted as a sign of the pluripotency what can in turn explain the diversity of histologic lineages present in this tumour.
dc.format.extent6 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec658902
dc.identifier.issn1699-8855
dc.identifier.urihttps://hdl.handle.net/2445/119034
dc.language.isoeng
dc.publisherElsevier España
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.patol.2014.10.002
dc.relation.ispartofRevista Española de Patología, 2014, vol. 48, p. 170-175
dc.relation.urihttps://doi.org/10.1016/j.patol.2014.10.002
dc.rights(c) Sociedad Española de Anatomía Patológica y Sociedad Española de Citología, 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Fonaments Clínics)
dc.subject.classificationCàncer de mama
dc.subject.classificationTumors
dc.subject.classificationOncologia
dc.subject.otherBreast cancer
dc.subject.otherTumors
dc.subject.otherOncology
dc.titleExuberant complex metaplastic carcinoma of the breast with sox2 expression: covering the full spectrum of ductal neoplasia of the breast
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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