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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183067
Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact.
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BACKGROUND NlmCategory: BACKGROUND content:
Population-wide interventions using malaria testing and
treatment might decrease the reservoir of Plasmodium falciparum
infection and accelerate towards elimination. Questions remain
about their effectiveness and evidence from different
transmission settings is needed. - Label: METHODS NlmCategory:
METHODS content: "A pilot quasi-experimental study to evaluate a
package of population-wide test and treat interventions was
conducted in six health facility catchment areas (HFCA) in the
districts of Kanel, Lingu\xC3\xA8re, and Ran\xC3\xA9rou
(Senegal). Seven adjacent HFCAs were selected as comparison.
Villages within the intervention HFCAs were stratified according
to the 2013 incidences of passively detected malaria cases, and
those with an incidence\xE2\x80\x89\xE2\x89\xA5\xE2\x80\x8915
cases/1000/year were targeted for a mass test and treat (MTAT)
in September 2014. All households were visited, all consenting
individuals were tested with a rapid diagnostic test (RDT), and,
if positive, treated with dihydroartemisinin-piperaquine. This
was followed by weekly screening, testing and treatment of fever
cases (PECADOM++) until the end of the transmission season in
January 2015. Villages with lower incidence received only
PECADOM++ or case investigation. To evaluate the impact of the
interventions over that transmission season, the incidence of
passively detected, RDT-confirmed malaria cases was compared
between the intervention and comparison groups with a
difference-in-difference analysis using negative binomial
regression with random effects on HFCA." - Label: RESULTS
NlmCategory: RESULTS content: "During MTAT, 89% (2225/2503) of
households were visited and 86% (18,992/22,170) of individuals
were tested, for a combined 77% effective coverage. Among those
tested, 291 (1.5%) were RDT positive (range 0-10.8 by village),
of whom 82% were\xE2\x80\x89<\xE2\x80\x8920\xC2\xA0years old
and 70% were afebrile. During the PECADOM++ 40,002 visits were
conducted to find 2784 individuals reporting fever, with an RDT
positivity of 6.5% (170/2612). The combination of interventions
resulted in an estimated 38% larger decrease in malaria case
incidence in the intervention compared to the comparison group
(adjusted incidence risk ratio\xE2\x80\x89=\xE2\x80\x890.62, 95%
CI 0.45-0.84, p\xE2\x80\x89=\xE2\x80\x890.002). The cost of the
MTAT was $14.3 per person." - Label: CONCLUSIONS NlmCategory:
CONCLUSIONS content: It was operationally feasible to conduct
MTAT and PECADOM++ with high coverage, although PECADOM++ was
not an efficient strategy to complement MTAT. The modest impact
of the intervention package suggests a need for alternative or
complementary strategies.
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CONNER, Ruben o., DIEYE, Yakou, HAINSWORTH, Michael, TALL, Adama, CISSE, Badara, FAYE, Farba, SY, Mame demba, BA, Amadou, SENE, Doudou, BA, Souleymane, DOUCOURÉ, Elhadji, THIAM, Tidiane, DIOP, Moussa, SCHNEIDER, Kammerle, CISSÉ, Moustapha, BA, Mady, EARLE, Duncan, GUINOT, Philippe, STEKETEE, Richard w., GUINOVART, Caterina. Mass testing and treatment for malaria followed by weekly fever
screening, testing and treatment in Northern Senegal:
feasibility, cost and impact.. _Malaria Journal_. 2020. Vol. vol 19. [consulta: 25 de gener de 2026]. ISSN: 1475-2875. [Disponible a: https://hdl.handle.net/2445/183067]