Proteomics and the genetics of sperm chromatin condensation

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dc.contributor.authorOliva Virgili, Rafael
dc.contributor.authorCastillo Corullón, Judit
dc.date.accessioned2022-10-28T16:00:10Z
dc.date.available2022-10-28T16:00:10Z
dc.date.issued2011-01
dc.date.updated2022-10-28T16:00:11Z
dc.description.abstractSpermatogenesis involves extremely marked cellular, genetic and chromatin changes resulting in the generation of the highly specialized sperm cell. Proteomics allows the identification of the proteins that compose the spermatogenic cells and the study of their function. The recent developments in mass spectrometry (MS) have markedly increased the throughput to identify and to study the sperm proteins. Catalogs of thousands of testis and spermatozoan proteins in human and different model species are becoming available, setting up the basis for subsequent research, diagnostic applications and possibly the future development of specific treatments. The present review intends to summarize the key genetic and chromatin changes at the different stages of spermatogenesis and in the mature sperm cell and to comment on the presently available proteomic studies.
dc.format.extent7 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec590079
dc.identifier.issn1008-682X
dc.identifier.pmid21042303
dc.identifier.urihttps://hdl.handle.net/2445/190302
dc.language.isoeng
dc.publisherWolters Kluwer - Medknow
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/aja.2010.65
dc.relation.ispartofAsian Journal of Andrology, 2011, vol. 13, num. 1, p. 24-30
dc.relation.urihttps://doi.org/10.1038/aja.2010.65
dc.rightscc-by-nc-sa (c) Oliva Virgili, Rafael et al., 2011
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceArticles publicats en revistes (Biomedicina)
dc.subject.classificationEpigenètica
dc.subject.classificationEspermatozoides
dc.subject.classificationEspermatogènesi
dc.subject.classificationProtamines
dc.subject.classificationProteòmica
dc.subject.otherEpigenetics
dc.subject.otherSpermatozoa
dc.subject.otherSpermatogenesis
dc.subject.otherProtamines
dc.subject.otherProteomics
dc.titleProteomics and the genetics of sperm chromatin condensation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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