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Article

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2012-03-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/158701

Thymidine- and AZT-linked 5-(1,3-dioxoalkyl)tetrazoles and 4-(1,3-dioxoalkyl)-1,2,3-triazoles

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https://doi.org/10.1016/j.tetlet.2011.11.079

Abstract

N3 of thymidine and of 3′-azido-3′-deoxythymidine (AZT) has been linked to a tetrazole ring by condensation of nucleoside-derived 2-oxonitriles with the lithium salt of 5-acetyl-1-(4-fluorobenzyl)tetrazole (obtained by a 'click' reaction). 4-Acetyl-1,2,3-triazole, also prepared by a Cu-catalysed cycloaddition, has been similarly linked. A route for the conjugation of NRTIs with pharmacophoric elements of integrase inhibitors (INIs) has thus been disclosed.

Subject

VIH (Virus), Inhibidors de la integrasa, Integrase inhibitors

Subject (English)

HIV (Viruses)

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Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

BOSCH HEREU, Lluís, et al. Thymidine- and AZT-linked 5-(1,3-dioxoalkyl)tetrazoles and 4-(1,3-dioxoalkyl)-1,2,3-triazoles. Tetrahedron Letters. 2012. Vol. 53, num. 3, pags. 514-518. ISSN 0040-4039. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/158701

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