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2010

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cc-by-nc (c) Amat Tusón, Mercedes et al., 2010
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/61086

Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity

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http://dx.doi.org/10.3998/ark.5550190.0011.313

Abstract

A straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported.

Subject

Bioquímica, Amines, Dianes farmacològiques, Proteïnes quinases, Transducció de senyal cel·lular

Subject (English)

Biochemistry, Amines, Drug targeting, Protein kinases, Cellular signal transduction

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citation

AMAT TUSÓN, Mercedes, et al. Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity. Arkivoc. vol. 2010. Vol. 3, num. 145-151. ISSN 1551-7012. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/61086

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