Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity

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dc.contributor.authorAmat Tusón, Mercedes
dc.contributor.authorKöver, Andrea
dc.contributor.authorJokic, Danica
dc.contributor.authorLozano, Oscar
dc.contributor.authorPérez Bosch, Maria
dc.contributor.authorLandoni, Nicola
dc.contributor.authorSubrizi, Fabiana
dc.contributor.authorBautista, Jesús
dc.contributor.authorBosch Cartes, Joan
dc.date.accessioned2015-01-08T18:30:18Z
dc.date.available2015-01-08T18:30:18Z
dc.date.issued2010
dc.date.updated2015-01-08T18:30:19Z
dc.description.abstractA straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported.
dc.format.extent7 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec568739
dc.identifier.issn1551-7012
dc.identifier.urihttps://hdl.handle.net/2445/61086
dc.language.isoeng
dc.publisherMichigan Publishing
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.3998/ark.5550190.0011.313
dc.relation.ispartofArkivoc, vol. 2010, núm. 3, p. 145-151
dc.relation.urihttp://dx.doi.org/10.3998/ark.5550190.0011.313
dc.rightscc-by-nc (c) Amat Tusón, Mercedes et al., 2010
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationBioquímica
dc.subject.classificationAmines
dc.subject.classificationDianes farmacològiques
dc.subject.classificationProteïnes quinases
dc.subject.classificationTransducció de senyal cel·lular
dc.subject.otherBiochemistry
dc.subject.otherAmines
dc.subject.otherDrug targeting
dc.subject.otherProtein kinases
dc.subject.otherCellular signal transduction
dc.titleSynthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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