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2015-03-31

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cc by (c) Tikk, Kaja et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126145

Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study

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https://doi.org/10.1186/s13058-015-0563-6

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Introduction: The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention. Methods: We analysed the relationship between pre-diagnostic prolactin levels and the risk of in situ breast cancer overall, and by menopausal status and use of postmenopausal hormone therapy (HT) at blood donation. Conditional logistic regression was used to assess this association in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, including 307 in situ breast cancer cases and their matched control subjects. Results: We found a significant positive association between higher circulating prolactin levels and risk of in situ breast cancer among all women [pre-and postmenopausal combined, ORlog2 = 1.35 (95% CI 1.04-1.76), P-trend = 0.03]. No statistically significant heterogeneity was found between prolactin levels and in situ cancer risk by menopausal status (P-het = 0.98) or baseline HT use (P-het = 0.20), although the observed association was more pronounced among postmenopausal women using HT compared to non-users (P-trend = 0.06 vs P-trend = 0.35). In subgroup analyses, the observed positive association was strongest in women diagnosed with in situ breast tumors <4 years compared to >= 4 years after blood donation (P-trend = 0.01 vs P-trend = 0.63; P-het = 0.04) and among nulliparous women compared to parous women (P-trend = 0.03 vs P-trend = 0.15; P-het = 0.07). Conclusions: Our data extends prior research linking prolactin and invasive breast cancer to the outcome of in situ breast tumours and shows that higher circulating prolactin is associated with increased risk of in situ breast cancer. The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention.

Matèries

Càncer de mama, Prolactina

Matèries (anglès)

Breast cancer, Prolactin

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

TIKK, Kaja, SOOKTHAI, Disorn, FORTNER, Renée t., JOHNSON, Theron, RINALDI, Sabina, ROMIEU, Isabelle, TJØNNELAND, Anne, OLSEN, Anja, OVERVAD, Kim, CLAVEL-CHAPELON, Françoise, BAGLIETTO, Laura, BOEING, Heiner, TRICHOPOULOU, Antonia, LAGIOU, Pagona, TRICHOPOULOS, Dimitrios, MASALA, Giovanna, KROGH, Vittorio, TUMINO, Rosario, RICCERI, Fulvio, MATTIELLO, Amalia, AGUDO, Antonio, MENÉNDEZ, Virginia, SÁNCHEZ, María josé, AMIANO, Pilar, CHIRLAQUE, María dolores, BARRICARTE, Aurelio, BUENO DE MESQUITA, H. bas, MONNINKHOF, Evelyn m., ONLAND-MORET, N. charlotte, ANDRESSON, Anne, SUND, Malin, WEIDERPASS, Elisabete, KHAW, Kay-tee, KEY, Timothy j., TRAVIS, Ruth c., MERRITT, Melissa a., RIBOLI, Elio, DOSSUS, Laure, KAAKS, Rudolf. Circulating prolactin and in situ breast cancer risk
in the European EPIC cohort: a case-control study. _Breast Cancer Research_. 2015. Vol. 17, núm. 49. [consulta: 24 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/126145]

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