Miniatura

Fitxers

679446.pdf (2.4 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2017-08-25

Llicència de publicació

cc-by (c) Morató Arús, Xavier et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/121969

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/s41598-017-10147-x

Resum

G protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson's disease (PD) neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A2A receptor (A2AR) cell surface expression and function in vivo. In addition, we showed that GPR37 and A2AR do oligomerize in the striatum. Thus, a close proximity of GPR37 and A2AR at the postsynaptic level of striatal synapses was observed by double-labelling post-embedding immunogold detection. Indeed, the direct receptor-receptor interaction was further substantiated by proximity ligation in situ assay. Interestingly, GPR37 deletion promoted striatal A2AR cell surface expression that correlated well with an increased A2AR agonist-mediated cAMP accumulation, both in primary striatal neurons and nerve terminals. Furthermore, GPR37−/− mice showed enhanced A2AR agonist-induced catalepsy and an increased response to A2AR antagonist-mediated locomotor activity. Overall, these results revealed a key role for GPR37 controlling A2AR biology in the striatum, which may be relevant for PD management.

Matèries

Malaltia de Parkinson, Proteïnes G, Adenosina, Marcadors bioquímics, Receptors de neurotransmissors

Matèries (anglès)

Parkinson's disease, G Proteins, Adenosine, Biochemical markers, Neurotransmitter receptors

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
<b>Publicacions de projectes de recerca finançats per la UE</b>
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MORATÓ ARÚS, Xavier, LUJÁN, Rafael, LÓPEZ-CANO, Marc, GANDÍA SÁNCHEZ, Jorge, STAGLJAR, Igor, WATANABE, Masahiko, CUNHA, Rodrigo a., FERNÁNDEZ DUEÑAS, Víctor, CIRUELA ALFÉREZ, Francisco. The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo. _Scientific Reports_. 2017. Vol. 7, núm. 1, pàgs. 9452. [consulta: 27 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/121969]

Exportar metadades

JSON - METS

Compartir registre