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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/175806
Myositis and Cancer
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Abstract
The idiopathic inflammatory myopathies (IIM), classically dermatomyositis (DM),
polymyositis (PM), and inclusion body myositis (IBM), are acquired systemic autoimmune
disorders defined by chronic muscle weakness and inflammation of unknown aetiology.
The combination of clinical, laboratory, electromyographic, and histological features is the
basis of diagnosis, as well as exclusion of several mimicking conditions (Bohan & Peter,
1975; Dalakas & Hohlfeld, 2003; Mann et al, 2010; Mastaglia & Phillips, 2002). IIM are the
most common causes of acquired muscle disease in adults, but are still rare conditions with
an estimated overall prevalence of 50 to 100 cases per million (Oddis et al., 1990; Prieto &
Grau 2010; Wilson et al., 2008).
In recent years, taking into account additional clinical, immunological and histological
features, new phenotypes among IIM, such as antisynthetase syndrome, autoimmune
necrotizing myopathy, connective tissue disorder-associated myositis, or cancer-associated
myositis (CAM), have been described (Cox et al., 2010; Dalakas, 2010; Dimachkie, 2011;
Rider & Miller, 2011; Targoff, 2008).
The association between cancer and IIM has been widely reported in the medical literature,
particularly in DM patients (Buchbinder et al., 2001; Sigurgeirsson et al., 1992). Cancer
screening is a common practice in patients recently diagnosed with IIM, but there is not
consensus about how, and how often screening should be performed. The aim of this
chapter is to describe the epidemiological, clinical, laboratory, and histological reported
features about CAM, to analyze the current potentially approach to preclude malignancy in
IIM, and to provide an advisable algorithm in the diagnosis of occult cancer in myositis.
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PRIETO GONZÁLEZ, Sergio, et al. Myositis and Cancer. Chapter 7 in: Gran. Jan Tore. 2011. Idiopathic Inflammatory Myopathies - Recent Developments. IntechOpen. ISBN: 978-953-51-6490-6. DOI: 10.5772/814. pp: 111-122.. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/175806