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2016

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cc-by-nc-nd (c) Elsevier, 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/128127

Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition

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Recurs relacionat

https://doi.org/10.1016/j.ccell.2016.11.004

Resum

Cirrhosis is a milieu that develops hepatocellular carcinoma (HCC), the second most lethal cancer worldwide. HCC prediction and prevention in cirrhosis are key unmet medical needs. Here we have established an HCC risk gene signature applicable to all major HCC etiologies: hepatitis B/C, alcohol, and non-alcoholic steatohepatitis. A transcriptome meta-analysis of >500 human cirrhotics revealed global regulatory gene modules driving HCC risk and the lysophosphatidic acid pathway as a central chemoprevention target. Pharmacological inhibition of the pathway in vivo reduced tumors and reversed the gene signature, which was verified in organotypic ex vivo culture of patient-derived fibrotic liver tissues. These results demonstrate the utility of clinical organ transcriptome to enable a strategy, namely, reverse-engineering precision cancer prevention.

Matèries

Càncer de fetge, Cirrosi hepàtica

Matèries (anglès)

Liver cancer, Hepatic cirrhosis

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

NAKAGAWA, Shigeki, WEI, Lan, SONG, Won min, HIGASHI, Takaaki, GHOSHAL, Sarani, KIM, Rosa s., BIAN, C. billie, YAMADA, Suguru, SUN, Xiaochen, VENKATESH, Anu, GOOSSENS, Nicolas, BAIN, Gretchen, LAUWERS, Gregory y., KOH, A. p., EL-ABTAH, Mohamed, AHMAD, Noor b., HOSHIDA, Hiroki, ERSTAD, Derek j., GUNASEKARAN, Ganesh, LEE, Youngmin, YU, Ming-lung, CHUANG, Wan-long, DAI, Chia-yen, KOBAYASHI, Masahiro, KUMADA, Hiromitsu, BEPPU, Toru, BABA, Hideo, MAHAJAN, Milind, NAIR, Venugopalan d., LANUTI, Michael, VILLANUEVA, Augusto, SANGIOVANNI, Angelo, IAVARONE, Massimo, COLOMBO, Massimo, LLOVET I BAYER, Josep maria, SUBRAMANIAN, Aravind, TAGER, Andrew m., FRIEDMAN, Scott l., BAUMERT, Thomas f., SCHWARTZ, Myron, CHUNG, Raymond t., TANABE, Kenneth k., ZHANG, Bin, FUCHS, Bryan c., HOSHIDA, Yujin, Precision Liver Cancer Prevention Consortium. Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition. _Cancer Cell_. 2016. Vol. 30, núm. 6, pàgs. 879-890. [consulta: 15 de gener de 2026]. ISSN: 1535-6108. [Disponible a: https://hdl.handle.net/2445/128127]

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