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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/125691
Untangling dopamine-adenosine receptor assembly in experimental parkinsonism in rats
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Parkinson's disease (PD) is a dopaminergic-related pathology in which functioning of the basal ganglia is altered. It has been postulated that a direct receptor-receptor interaction - i.e. of dopamine D-2 receptor (D2R) with adenosine A(2A) receptor (A(2A)R) (forming D2R-A(2A)R oligomers) - finely regulates this brain area. Accordingly, elucidating whether the pathology prompts changes to these complexes could provide valuable information for the design of new PD therapies. Here, we first resolved a long-standing question concerning whether D2R-A(2A)R assembly occurs in native tissue: by means of different complementary experimental approaches (i.e. immunoelectron microscopy, proximity ligation assay and TR-FRET), we unambiguously identified native D2R-A(2A)R oligomers in rat striatum. Subsequently, we determined that, under pathological conditions (i.e. in a rat PD model), D2R-A(2A)R interaction was impaired. Collectively, these results provide definitive evidence for alteration of native D2R-A(2A)R oligomers in experimental parkinsonism, thus conferring the rationale for appropriate oligomer-based PD treatments.
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FERNÁNDEZ DUEÑAS, Víctor, TAURA, Jaume, COTTET, Martin, GÓMEZ SOLER, Maricel, LÓPEZ-CANO, Marc, LEDENT, Catherine, WATANABE, Masahiko, TRINQUET, Eric, PIN, Jean-philippe, LUJÁN, Rafael, DURROUX, Thierry, CIRUELA ALFÉREZ, Francisco. Untangling dopamine-adenosine receptor assembly in experimental parkinsonism in rats. _Disease Models & Mechanisms_. 2015. Vol. 8, núm. 1, pàgs. 57-63. [consulta: 3 de febrer de 2026]. ISSN: 1754-8403. [Disponible a: https://hdl.handle.net/2445/125691]