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2025-07-16

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cc-by (c) García-Meilán, I. et al., 2025
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/223153

Modulation of digestive enzyme activities and intestinal γ-Proteobacteria in gilthead sea bream fed high-fat diets supplemented with HIDROX olive oil extract

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https://doi.org/10.3390/ani15142102

Abstract

High-fat diets are commonly used in fish farming due to their protein-sparing effect, contributing to reduced production costs. However, this practice may have adverse effects such as metabolic impairment and inflammation. These problems can be assessed in two ways: by developing functional diets or using food restriction, which leads to compensatory growth. The present study characterized digestion in gilthead sea bream fed a high-fat diet in the presence (HT) or absence (HF) of an olive oil polyphenol as an additive, hydroxytyrosol, under two different dietary regimes: feeding to satiation (ST) or at a 40% restriction (R). Digestive enzyme activities, specifically trypsin-like activities, were mainly upregulated by dietary treatment (HT). In contrast, restriction effects mainly appeared during digestion in the pyloric caeca, where a significant rise in chymotrypsin-like activities was detected. Moreover, those fish tended to have an increased relative intestinal length compared to those fish fed at a standard ration. Feed restriction enhanced the growth of γ-Proteobacteria in pyloric caeca and proximal intestinal regions, without altering their population in the distal intestine. Overall, it is suggested that hydroxytyrosol inclusion at a standard ration could improve digestion processes in gilthead sea bream fed high-fat diets under healthier conditions than without this additive.

Subject

Microbiota, Enzims proteolítics, Lipases

Subject (English)

Microbiota, Proteolytic enzymes, Lipase

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Citation

GARCÍA MEILÁN, Irene, et al. Modulation of digestive enzyme activities and intestinal γ-Proteobacteria in gilthead sea bream fed high-fat diets supplemented with HIDROX olive oil extract. Animals. 2025. Vol. 15, num. 14. ISSN 2076-2615. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/223153

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