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2023-10-27

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cc-by-nc-nd (c) Serra Mitjà, Pere et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/217540

Endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal staging of centrally located T1N0M0 non-small cell lung cancer clinically staged with positron emission tomography/computed tomography

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https://doi.org/10.1111/resp.14613

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Background and objective: To evaluate the diagnostic accuracy and clinical usefulness of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for mediastinal staging of centrally located T1N0M0 non-small cell lung cancer (NSCLC) clinically staged with positron emission tomography/computed tomography (PET/CT). Methods: We conducted a study that included patients with centrally located T1N0M0 NSCLC, clinically staged with PET/CT who underwent EBUS-TBNA for mediastinal staging. Patients with negative EBUS-TBNA underwent mediastinoscopy, video-assisted mediastinoscopic lymphadenectomy (VAMLA) and/or lung resection with systematic nodal dissection, that were considered the gold standard. The sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), overall accuracy of EBUS-TBNA for diagnosing mediastinal metastases (N2 disease) and the number needed to treat (NNT: number of patients needed to undergo EBUS-TBNA to avoid a case of pathologic N2 disease after resection) were calculated. Results: One-hundred eighteen patients were included. EBUS-TBNA proved N2 disease in four patients. In the remaining 114 patients who underwent mediastinoscopy, VAMLA and/or resection there were two cases of N2 (N2 prevalence 5.1%). The sensitivity, specificity, NPV, PPV and overall accuracy for diagnosing mediastinal metastases (N2 disease) were of 66%, 100%, 98%, 100% and 98%, respectively. The NNT was 31 (95% CI: 15-119). Conclusion: EBUS-TBNA in patients with central clinically staged T1N0M0 NSCLC presents a good diagnostic accuracy for mediastinal staging, even in a population with low prevalence of N2 disease. Therefore, its indication should be considered in the management of even these early lung cancers.

Matèries

Tomografia per emissió de positrons, Ganglis sentinelles, Càncer de pulmó, Ecografia, Diagnòstic per la imatge

Matèries (anglès)

Positron emission tomography, Sentinel lymph nodes, Lung cancer, Ultrasonic imaging, Diagnostic imaging

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

SERRA MITJÀ, Pere, GARCÍA CABO, Bruno, GARCIA OLIVÉ, Ignasi, RADUA, Joaquim, RAMI PORTA, Ramón, ESTEBAN, Lluís, BARREIRO, Bienvenido, CALL CAJA, Sergi, CENTENO, Carmen, ANDREO, Felipe, OBIOLS FORNELL, Carme, OCHOA, Juan manuel, MARTÍNEZ PALAU, Mireia, REIG, Nina, SERRA, Mireia, SANZ SANTOS, José. Endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal staging of centrally located T1N0M0 non-small cell lung cancer clinically staged with positron emission tomography/computed tomography. _Respirology_. 2023. Vol. 29, núm. 2, pàgs. 158-165. [consulta: 29 de gener de 2026]. ISSN: 1323-7799. [Disponible a: https://hdl.handle.net/2445/217540]

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