Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/196613
Oxidative Stress in Structural Valve Deterioration: A Longitudinal Clinical Study
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A) and BHV patients during the first 24 (Phase B1) and >48 months (Phase B2) after BHV implantation to assess total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrotyrosine (NT). The results show that MDA levels increased significantly 1 month after surgery in all groups but were higher at 6 months only in incipient SVD patients. NT levels increased gradually for the first 24 months after implantation in the BHV group. Patients with transcatheter aortic valve implantation (TAVI) showed even higher levels of stress markers. After >48 months, MDA and NT continued to increase in BHV patients with a further elevation after 60-72 months; however, these levels were significantly lower in the incipient and established SVD groups. In conclusion, oxidative stress may play a significant role in SVD, increasing early after BHV implantation, especially in TAVI cases, and also after 48 months' follow-up, but decreasing when SVD develops. Oxidative stress potentially represents a target of therapeutic intervention and a biomarker of BHV dysfunction.
Subject (English)
Citation
Citation
GALIÑANES, Manuel, et al. Oxidative Stress in Structural Valve Deterioration: A Longitudinal Clinical Study. Biomolecules. 2022. Vol. 12, num. 11, pags. 1606. ISSN 2218-273X. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/196613