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s10020-025-01313-3.pdf (1.65 MB)

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2025-07-27

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cc by (c) Batista Liz, Joao Carlos et al, 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222837

Evaluating the usefulness of C5 and C5AR1 as genetic biomarkers of IgA-mediated vasculitis

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https://doi.org/10.1186/s10020-025-01313-3

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BackgroundIgA-mediated vasculitis (IgAV) is a complex inflammatory disease. Unravelling its genetic background would allow us to identify genetic biomarkers that may be used as additional tools in its daily management, helping to solve the clinical challenge that this vasculitis entails. C5 is a potent immune mediator that is proteolytically processed to generate C5a, a potent anaphylatoxin that exerts its function via C5aR1. C5 downstream variants (rs3761847 and rs10818488) have been recently related to IgAV pathogenesis. Additionally, C5a and C5aR1 dysregulation contributes to the development of inflammatory diseases, and, particularly, elevated C5a plasma levels have been observed in IgAV patients in the acute stage. Accordingly, we aimed to evaluate the influence of C5 and C5AR1 on the pathophysiology of IgAV.MethodsEight C5 (rs10760128, rs74971050, rs4310279, rs7868761, rs10818495, rs10156396, rs3815467, and rs16910280) and three C5AR1 (rs10853784, rs11673071, and rs11670789) tag variants were genotyped in 342 Caucasian IgAV patients and 723 ethnically matched healthy controls.ResultsNo statistically significant differences were observed when C5 and C5AR1 frequencies were compared between IgAV patients and healthy controls. Likewise, similar C5 and C5AR1 frequencies were observed amongst IgAV patients stratified according to IgAV severity (presence/absence of nephritis). Furthermore, no C5 and C5AR1 differences were disclosed when IgAV patients were stratified according to demographic and clinical IgAV characteristics other than nephritis (age at disease onset, presence/absence of joint and gastrointestinal manifestations) and sex.ConclusionsOur results suggest that C5 and C5AR1 are not related to IgAV pathogenesis and, therefore, these genes may not be useful as IgAV genetic biomarkers.

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Immunoglobulines, Vasculitis

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Immunoglobulins, Vasculitis

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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LIZ, Joao carlos batista, CALVO RÍO, Vanesa, SEBASTIÁN MORA-GIL, María, LEONARDO, María teresa, CRISTINA PEÑALBA, Ana, MARTÍN PENAGOS, Luis, NARVÁEZ, Javier, SEVILLA PÉREZ, Belén, CALLEJAS RUBIO, José luis, GABRIE, Ligia, GÁLVEZ SÁNCHEZ, Rafael, CAMINAL MONTERO, Luis, COLLADO, Paz, RODRÍGUEZ VALLS, María josé, ARGILA, Diego de, QUIROGA COLINA, Patricia, VICENTE RBANEDA, Esther francisca, RUBIO, Esteban, LEÓN LUQUE, Manuel, BLANCO MADRIGAL, Juan maría, GALÍNDEZ AGIRREGOIKOA, Eva, BLANCO, Ricardo, PULITO CUETO, Verónica, LÓPEZ MEJÍAS, Raquel. Evaluating the usefulness of C5 and C5AR1 as genetic biomarkers of IgA-mediated vasculitis. _Molecular Medicine_. 2025. Vol. 31, núm. 1. [consulta: 20 de gener de 2026]. ISSN: 1528-3658. [Disponible a: https://hdl.handle.net/2445/222837]

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